(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane

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(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane Basic information
Product Name:(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane
Synonyms:(-)-(R,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran;Nebivolol Impurity 19;Nebivolol Impurity 24;(2R)-6-fluoro-2-[(2R)-oxiran-2-yl]-3,4-dihydro-2H-chromene;2H-1-Benzopyran, 6-fluoro-3,4-dihydro-2-[(2R)-2-oxiranyl]-, (2R)-;(2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane;Nebivolol Impurity 7;6-fluoro-3,4-dihydro-2-[(2R)-2-oxiranyl]-, (2R)-
CAS:197706-50-6
MF:C11H11FO2
MW:194.2
EINECS:606-373-1
Product Categories:
Mol File:197706-50-6.mol
(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane Structure
(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane Chemical Properties
Boiling point 291.7±40.0 °C(Predicted)
density 1.299±0.06 g/cm3(Predicted)
vapor pressure 0.12-0.22Pa at 20-25℃
form Liquid:viscous
LogP2.2-5.2 at 20℃ and pH7
Safety Information
MSDS Information
(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane Usage And Synthesis
Uses(2R,2’R)-6-Fluoro-2-(2’-oxiranyl)chromane is an intermediate to synthesize Nebivolol (rac, HCl salt, N387900) which is a β1-Adrenergic blocker.
(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane Preparation Products And Raw materials
Preparation ProductsNebivolol Impurity 3
Tag:(R)-6-Fluoro-2-[(R)-2-oxiranyl]chromane(197706-50-6) Related Product Information
(+-)-(R*,S*)-6-fluoro-3,4-dihydro-alpha-[[(phenylmethyl)amino]methyl]-2H-1-benzopyran-2-methanol 4-Hydroxy Nebivolol, Hydrochloride Hydrate (Mixture of Diastereomers) (-)-Nebivolol Nebivolol Impurity 10 HCl (RS,SR) (2S, 2’S)-6-Fluoro-2-(2’-oxiranyl)chromane Nebivolol Impurity 12 HCl (RR,RR) Nebivolol Impurity 28 HCl (SS,RS) 6-Fluoro-3,4-dihydro-2-oxiranyl-2H-1-benzopyran Ponazuril D-Nebivolol,hydrochloride(1:1) (+)-(S,R)-6-fluoro-3,4-dihydro-2-(2-oxiranyl)-2H-1-benzopyran (2R)-rel-6-Fluoro-3,4-dihydro-2-(2R)-2-oxiranyl-2H-1-benzopyran Defluoro Nebivolol (Mixture of DiastereoMers) (2S)-6-fluoro-2-(oxiran-2-yl)chromane Nebivolol Impurity 2 HCl (SR,RS) NEBIVOLOL HCL Nebivolol (R,R,S,R)-Isomer Nebivolol Impurity 3