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Nylidrin hydrochloride manufacturers
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| | Nylidrin hydrochloride Basic information |
| Product Name: | Nylidrin hydrochloride | | Synonyms: | Nylidrin, HCl;NYLIDRIN HYDROCHLORIDE B-ADRENERGIC AGON IST,;NYLIDRIN HYDROCHLORIDE 95%;Arlibide;Arlidin;Benzenemethanol, 4-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride;Benzyl alcohol, p-hydroxy-.alpha.-[1-[(1-methyl-3-phenylpropyl)amino]ethyl]-, hydrochloride;Buphedrin | | CAS: | 849-55-8 | | MF: | C19H26ClNO2 | | MW: | 335.87 | | EINECS: | 212-701-0 | | Product Categories: | | | Mol File: | 849-55-8.mol |  |
| | Nylidrin hydrochloride Chemical Properties |
| Melting point | 198-199℃ (decomposition) | | storage temp. | Store at -20°C | | solubility | DMSO: ≥ 41 mg/mL (122.07 mM) | | form | Solid | | color | White to Off-White |
| Hazard Codes | Xn | | Risk Statements | 20/21/22 | | Safety Statements | 36 | | WGK Germany | 3 | | RTECS | DO8300000 |
| | Nylidrin hydrochloride Usage And Synthesis |
| Chemical Properties | White, crystals or powder, odorless;
tasteless. Slightly soluble in water and alcohol; very
slightly soluble in chloroform, ether; pH of 1% solution is between 4.5 and 6.5. | | Originator | Buphenine
hydrochloride,Troponwerke | | Uses | Medicine (treatment of heart disease). | | Definition | ChEBI: Nylidrin hydrochloride is an alkylbenzene. | | Manufacturing Process | The p-benzoxy-α-bromopropiophenone and 1-phenyl-3-amino-butane were
heating for an hour on the water bath in the absence of solvents. A solid
crystalline cake was obtained. After being extracted with boiling acetic acid,
the hydrobromide of 1-(p-hydroxyphenyl)-2-(β-phenylbutylamino)propanone-1
was obtained.
The hydrobromide of 1-(p-hydroxyphenyl)-2-(β-phenylbutylamino)propanone-
1 was suspended in very pure methanol and shaken with a 10% palladium
hydroxide barium sulfate catalyst in contact with, hydrogen. After rather more
than 2 mols of hydrogen had been taken-up the hydrogenation stopped. The
1-(p-hydroxyphenyl)-2-(3-phenylbutylamino)propanol-1, was filtered, washed
with methanol and evaporated, melting point 110-111°C. | | Therapeutic Function | Vasodilator |
| | Nylidrin hydrochloride Preparation Products And Raw materials |
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