[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate manufacturers
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| | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Basic information |
| Product Name: | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate | | Synonyms: | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate;MPEG2000-DSPE Sodium Salt;1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol) sodium salt;DSPE-mPEG2000 sodium|||18:0 mPEG2000 PE sodium;mPEG-DSPE sodium;DSPE-mPEG2000 (Na salt) 1,2-dihydroxyacyl-sn-glycerol-3-phosphoryl ethanolamine polyethylene glycol 2000 (sodium salt);mPEG-DSPE (sodium salt);3-[[(2R,3S,5R)-2-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-5-(5-oxoimidazo[1,2-c]pyrimidin-6-yl)oxolan-3-yl]oxy-[di(propan-2-yl)amino]phosphanyl]oxypropanenitrile | | CAS: | 247925-28-6 | | MF: | C45H88NO11P | | MW: | 850.154081 | | EINECS: | | | Product Categories: | | | Mol File: | 247925-28-6.mol | ![[(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Structure](CAS/20200401/GIF/247925-28-6.gif) |
| | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Chemical Properties |
| solubility | Chloroform: 10 mg/ml
DMF: 2.5 mg/ml
DMF: PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | Solid | | color | White to off-white |
| | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Usage And Synthesis |
| Uses | 18:0 mPEG2000 PE sodium (DSPE-mPEG2000 (sodium)) is a conjugate of phospholipid and polyethylene glycol, and it can serve as an important PEG lipid component in lipid nanoparticles (LNPs). 18:0 mPEG2000 PE sodium can be used in the research of gene transfection, drug carriers and drug delivery[1][2]. | | References | [1] Miller AD. Delivery of RNAi therapeutics: work in progress. Expert Rev Med Devices. 2013;10(6):781-811. DOI:10.1586/17434440.2013.855471
[2] Zhang L, et al. DSPE-mPEG2000-Modified Podophyllotoxin Long-Circulating Liposomes for Targeted Delivery: Their Preparation, Characterization, and Evaluation. Curr Drug Deliv. 2025 Jan 2. DOI:10.2174/0115672018356666241224052638
[3] ZHANG J, LUO Y, ZHAO X, et al. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG2000–DSPE modified liposomes for the treatment of multidrug resistant breast cancer[J]. RSC Advances, 2016, 114: 113173-113184. DOI: 10.1039/c6ra24173e
[4] GULAM MUSTAFA HASAN. Inhibition of the Growth of Plasmodium falciparum in Culture by Stearylamine-Phosphatidylcholine Liposomes.[J]. Journal of Parasitology Research, 2011, 2011: 120462. DOI: 10.1155/2011/120462
[5] SHAILENDRA SINGH RATHORE Prahlad C G. Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: Effect of lysosomotropic agents[J]. International Journal of Pharmaceutics, 2008, 350 1: Pages 79-94. DOI: 10.1016/j.ijpharm.2007.08.032
[6] FATEME HAGHIRALSADAT. A comprehensive mathematical model of drug release kinetics from nano-liposomes, derived from optimization studies of cationic PEGylated liposomal doxorubicin formulations for drug-gene delivery.[J]. Artificial Cells, Nanomedicine, and Biotechnology, 2018, 46 1: 169-177. DOI: 10.1080/21691401.2017.1304403 |
| | [(2R)-2,3-di(octadecanoyloxy)propyl] 2-(2-methoxyethoxycarbonylamino)ethyl phosphate Preparation Products And Raw materials |
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