(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid

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(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Basic information
Product Name:(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid
Synonyms:(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid;SF 2312(SF2312);Phosphonic acid, P-(1,5-dihydroxy-2-oxo-3-pyrrolidinyl)-
CAS:107729-45-3
MF:C4H8NO6P
MW:197.08
EINECS:
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Mol File:107729-45-3.mol
(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Structure
(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Chemical Properties
Boiling point 588.1±60.0 °C(Predicted)
density 2.01±0.1 g/cm3(Predicted)
pka1.25±0.40(Predicted)
form Oil
color Light yellow to yellow
Safety Information
MSDS Information
(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Usage And Synthesis
UsesSF2312, a natural phosphonate antibiotic (Antibiotic), is a highly potent Enolase inhibitor with IC50s of 37.9 nM and 42.5 nM for human recombinant ENO1 and ENO2, respectively. SF2312 is active against bacteria under anaerobic conditions[1].
References[1] Paul G Leonard, et al. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec;12(12):1053-1058. DOI:10.1038/nchembio.2195
(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Preparation Products And Raw materials
Tag:(1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid(107729-45-3) Related Product Information
SF2312 ammonium (1,5-dihydroxy-2-oxopyrrolidin-3-yl)phosphonic acid Doxorubicin hydrochloride Carbonyl cyanide 3-chlorophenylhydrazone Brefeldin A Adenosine triphosphate