| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
P-gp inhibitor 1 manufacturers
- P-gp inhibitor 1
-
- $37.00
-
2026-08-08
- CAS:2050747-49-2
- Purity: 98.65%
- Supply Ability: 10g
- P-gp inhibitor 1
-
- $37.00
-
2026-08-08
- CAS:2050747-49-2
- Purity: 98.65%
- Supply Ability: 10g
|
| | P-gp inhibitor 1 Basic information |
| Product Name: | P-gp inhibitor 1 | | Synonyms: | P-gp inhibitor 1;4-Quinazolinamine, N-[4-[2-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)ethyl]phenyl]-2-(4-pyridinyl)-;P-glycoprotein,inhibit,Pgp inhibitor 1,P-gp inhibitor 1,Pgp,P-gp,CD243,MDR1,Cluster of differentiation 243,Multidrug resistance protein 1,Inhibitor,ABCB1,P gp inhibitor 1;P- p inhibitor 1;P-gp inhibitor 1, 10 mM in DMSO;N-(4-(2-(6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)-yl)ethyl)phenyl)-2-(pyridin-4-yl)quinazolin-4-amine | | CAS: | 2050747-49-2 | | MF: | C32H31N5O2 | | MW: | 517.62 | | EINECS: | | | Product Categories: | | | Mol File: | 2050747-49-2.mol |  |
| | P-gp inhibitor 1 Chemical Properties |
| storage temp. | 4°C, protect from light | | solubility | DMSO : 16.67 mg/mL (32.21 mM; ultrasonic and warming and heat to 70°C) | | form | Solid | | color | Light yellow to brown |
| | P-gp inhibitor 1 Usage And Synthesis |
| Uses | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. | | Biological Activity | P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance.
P-gp inhibitor 1 (12k) possesses high potency (EC50=57.9±3.5 nM), low cytotoxicity, and long duration of activity in reversing doxorubicin (DOX) resistance in K562/A02 cells (1 μM, 80 minutes)[1]. P-gp inhibitor 1 also boosts the potency of other MDR-related cytotoxic agents with different structures, increases accumulation of DOX, blocks Pgp-mediated Rh123 efflux, and suppresses P-gp ATPase activity in K562/A02 MDR cells (0.1, 1, 5 μM, 1 hour)[1]. | | References | [1]. Qiu Q, et al. Design, Synthesis, and Pharmacological Characterization of N-(4-(2 (6,7-Dimethoxy-3,4-dihydroisoquinolin-2(1H)yl)ethyl)phenyl)quinazolin-4-amine Derivatives: Novel Inhibitors Reversing P-Glycoprotein-Mediated Multidrug Resistance. J Med Chem. 2017 Apr 27;60(8):3289-3302. |
| | P-gp inhibitor 1 Preparation Products And Raw materials |
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