1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole

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1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole manufacturers

  • SC-58125
  • SC-58125 pictures
  • $35.00
  • 2026-07-27
  • CAS:162054-19-5
  • Purity: 99.81%
  • Supply Ability: 10g
1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole Basic information
Product Name:1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole
Synonyms:SC-58125;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)pyrazole;5-(4-Fluoro-phenyl)-1-(4-methanesulfonyl-phenyl)-3-trifluoromethyl-1H-pyrazole;5-(4-Fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-1H-pyrazole;1H-Pyrazole, 5-(4-fluorophenyl)-1-[4-(methylsulfonyl)phenyl]-3-(trifluoromethyl)-;Cyclooxygenase,cancer,SC58125,COX,Inhibitor,SC-58125,inflammatory,antitumor,COX-2,edema,inhibit;SC-58125, 10 mM in DMSO;SC-58125 ，E0789
CAS:162054-19-5
MF:C17H12F4N2O2S
MW:384.35
EINECS:
Product Categories:
Mol File:162054-19-5.mol
1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole Structure
1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole Chemical Properties
storage temp. Store at +4°C
solubility DMSO: ≥20mg/mL
form powder
color white to off-white
InChI1S/C17H12F4N2O2S/c1-26(24,25)14-8-6-13(7-9-14)23-15(10-16(22-23)17(19,20)21)11-2-4-12(18)5-3-11/h2-10H,1H3
InChIKeyJHBIMJKLBUMNAU-UHFFFAOYSA-N
SMILESCS(=O)(=O)c1ccc(cc1)-n2nc(cc2-c3ccc(F)cc3)C(F)(F)F
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45-24/25-22
WGK Germany 3
Storage Class11 - Combustible Solids
MSDS Information
1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
UsesSC-58125 is a selective cyclooxygenase 2 (COX-2) inhibitor with anti-inflammatory properties. SC-58125 blocks edema and hyperalgesia without causing gastric mucosal damage. SC-58125 also displays anti tumor activity.
DefinitionChEBI: A member of the class of pyrazoles that is 1H-pyrazole substituted by a 4-fluorophenyl group at position 5, a 4-(methylsulfonyl)phenyl group at position 1 and a trifluoromethyl group at position 3. A selective cyclooxygenase 2 inhibitor it exhibits anticancer property.
Biological ActivitySelective cyclooxygenase 2 (COX-2) inhibitor (IC 50 values are 0.04 and >100 μ M for COX-2 and COX-1 respectively). Anti-inflammatory; blocks edema and hyperalgesia in vivo following an inflammatory insult, without causing gastric mucosal damage. Also displays antitumor activity.
in vivo

SC-58125 (10 mg/kg; i.p. every 48 h) inhibits the growth of established colorectal cancer xenografts in mice[3].
SC-58125 (10 mg/kg; a single i.p.) reduces tumor PGE2 levels in mice[3].
SC-58125 (10 mg/kg; a single i.p.) does not change the tumor levels of COX-1 and COX-2 protein in mice[3].

Animal Model:Athymic Sprague-Dawley mice are injected HCA-7 cells[3]
Dosage:10 mg/kg
Administration:I.p. every 48 h; at the time of tumor implantation or 2 and 4 weeks later
Result:Decreased the tumor growth rates significantly.
IC 50hCOX-2: 0.04 μM (IC50); hCOX-1: >100 μM (IC50)
1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole Preparation Products And Raw materials
Tag:1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole(162054-19-5) Related Product Information
2-Methylindole Stearyl Methacrylate (S)-(+)-Benzyl glycidyl ether 2-Methylpropanedioic acid p-Tolualdehyde 4'-Hydroxyacetophenone 5-Phenyl-3-(trifluoromethyl)pyrazole 1-[(4-Methylsulfonyl)phenyl]-3-trifluoromethyl-5-(4-fluorophenyl)pyrazole 1,5-Diphenyl-3-trifluoromethyl-1H-pyrazole 1,5-Diphenyl-3-methyl-1H-pyrazole 3-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE 3-(4-Fluorophenyl)-1H-pyrazole 5-(TRIFLUOROMETHYL)-3-(4-FLUOROPHENYL)-1H-PYRAZOLE 3-DIFLUOROMETHYL-5-PHENYLPYRAZOLE 3-TRIFLUOROMETHYL-5-METHYL-1-(PHENYL)PYRAZOLE