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SB 200646 hydrochloride

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SB 200646 hydrochloride manufacturers

  • SB-200646A
  • SB-200646A pictures
  • $35.00
  • 2026-07-15
  • CAS:143797-62-0
  • Purity:
  • Supply Ability: 10g
SB 200646 hydrochloride Basic information
Product Name:SB 200646 hydrochloride
Synonyms:SB-200646A;SB 200646A,SB200646A;SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist;1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride;SB-200646A ，S0893
CAS:143797-62-0
MF:C15H14N4O.ClH
MW:302.763
EINECS:
Product Categories:
Mol File:143797-62-0.mol
SB 200646 hydrochloride Structure
SB 200646 hydrochloride Chemical Properties
storage temp. Inert atmosphere,Room Temperature
solubility DMSO: ~26 mg/mL, soluble
form solid
color pale yellow
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36
WGK Germany 3
MSDS Information
SB 200646 hydrochloride Usage And Synthesis
UsesSB 200646 Hydrochloride is a 5-HT2C antagonist.
in vivo

SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1].

Animal Model:Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1]
Dosage:20 mg/kg
Administration:Intravenous injection; daily; for 21 days
Result:Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
IC 505-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi)
SB 200646 hydrochloride Preparation Products And Raw materials
Tag:SB 200646 hydrochloride(143797-62-0) Related Product Information
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