SB 200646 HYDROCHLORIDE manufacturers
- SB-200646A
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- $35.00 / 2mg
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2026-01-04
- CAS:143797-62-0
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | SB 200646 HYDROCHLORIDE Basic information |
| Product Name: | SB 200646 HYDROCHLORIDE | | Synonyms: | SB-200646A;SB 200646A,SB200646A;SB 200646 hydrochloride, 5-HT2C/2B receptor antagonist;1-(1-Methyl-1H-indol-5-yl)-3-(pyridin-3-yl)urea hydrochloride;SB-200646A ，S0893 | | CAS: | 143797-62-0 | | MF: | C15H14N4O.ClH | | MW: | 302.763 | | EINECS: | | | Product Categories: | | | Mol File: | 143797-62-0.mol |  |
| | SB 200646 HYDROCHLORIDE Chemical Properties |
| storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO: ~26 mg/mL, soluble | | form | solid | | color | pale yellow |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 |
| | SB 200646 HYDROCHLORIDE Usage And Synthesis |
| Uses | SB 200646 Hydrochloride is a 5-HT2C antagonist. | | in vivo | SB-200646A (20 mg/kg; intravenous injection; daily; for 21 days; male albino Sprague-Dawley rats) treatment significantly decreases the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons[1].
The i.v. administration of 4-16 mg/kg of SB-200646A significantly increases the firing rate and % events as bursts in spontaneously active VTA dopaminergic neurons and significantly increases the % events as burst in substantia nigra pars compacta (SNC) dopaminergic neurons[1]. | Animal Model: | Male albino Sprague-Dawley rats (200-225 g at the beginning of treatment and 300-350 g at the time of the experiment)[1] | | Dosage: | 20 mg/kg | | Administration: | Intravenous injection; daily; for 21 days | | Result: | Significantly decreased the number of spontaneously active ventral tegmental area (VTA) dopaminergic neurons.
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| | IC 50 | 5-HT2B Receptor: 7.5 (pKi); 5-HT2C Receptor: 6.9 (pKi); 5-HT2A Receptor: 5.2 (pKi) |
| | SB 200646 HYDROCHLORIDE Preparation Products And Raw materials |
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