| Company Name: |
Energy Chemical |
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400-0056266 |
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marketing1@energy-chemical.com |
| Company Name: |
TargetMol |
| Tel: |
400-821-0310 15002144251 |
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xuexiang.shao@tsbiochem.com |
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| | Octanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- Basic information |
| | Octanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- Chemical Properties |
| Boiling point | 515.8±40.0 °C(Predicted) | | density | 1.086±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: 20mg/mL, clear | | pka | 9.79±0.10(Predicted) | | form | powder | | color | white to beige | | InChI | 1S/C16H25NO3/c1-2-3-4-5-6-7-16(20)17-11-10-13-8-9-14(18)15(19)12-13/h8-9,12,18-19H,2-7,10-11H2,1H3,(H,17,20) | | InChIKey | MGRVMTGNRVNIEL-UHFFFAOYSA-N | | SMILES | OC1=C(O)C=CC(CCNC(CCCCCCC)=O)=C1 |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | Octanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- Usage And Synthesis |
| Uses | N-Octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. N-Octanoyl dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells[1][2]. | | Biological Activity | N-Octanoyl dopamine (NOD) protects cell cultures and tissues from cold storage inflicted damage. N-Octanoyl dopamine decreases lactate-dehydrogenase (LDH) release during cold storage of cardiomyocytes in vitro. NOD did not induce a significant elevation of intracellular cAMP and is devoid of dopaminergic and adrenergic action. | | References | [1] Sivakkanan Loganathan, et al. N-octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. Pharmacol Res. 2019 Dec:150:104503. DOI:10.1016/j.phrs.2019.104503
[2] Bjrn B Hofmann, et al. N-Octanoyl-Dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells. Sci Rep. 2019 Dec 18;9(1):19338. DOI:10.1038/s41598-019-55983-1 |
| | Octanamide, N-[2-(3,4-dihydroxyphenyl)ethyl]- Preparation Products And Raw materials |
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