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| | 17(R)-Resolvin D3 Basic information |
| Product Name: | 17(R)-Resolvin D3 | | Synonyms: | 17(R)-Resolvin D3;5,7,9,13,15,19-Docosahexaenoic acid, 4,11,17-trihydroxy-, (4S,5Z,7E,9E,11R,13Z,15E,17R,19Z)- | | CAS: | 1427475-53-3 | | MF: | C22H32O5 | | MW: | 376.49 | | EINECS: | | | Product Categories: | | | Mol File: | 1427475-53-3.mol |  |
| | 17(R)-Resolvin D3 Chemical Properties |
| Boiling point | 609.2±55.0 °C(Predicted) | | density | 1.101±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: unstable; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.5 mg/ml | | pka | 4.56±0.10(Predicted) |
| | 17(R)-Resolvin D3 Usage And Synthesis |
| Description | 17(R)-Resolvin D3 (17(R)-RvD3) is an aspirin-triggered epimer of resolvin D3 .1 It is produced from docosahexaenoic acid (DHA; ) by COX-2 in the presence of aspirin via a 17(R)-hydroperoxy DHA (17(R)-HDHA; ) intermediate and has been found in mouse inflammatory exudates.1,2 17(R)-RvD3 reduces transmigration of isolated human polymorphonuclear cells (PMNs) and induces efferocytosis of apoptotic PMNs by macrophages.2 17(R)-RvD3 (10 ng/animal) reduces transmigration of neutrophils into the peritoneal cavity, as well as decreases the levels of IL-6 and increases the levels of IL-10 in inflammatory exudate in a mouse model of zymosan-induced peritonitis. It activates GPR32 in a β-arrestin reporter assay and increases phagocytosis to a greater degree in CHO cells overexpressing GPR32 compared to mock-transfected cells. 17(R)-RvD3 increases phagocytosis of etoposide-generated tumor cell debris by monocyte-derived macrophages in H460 human lung carcinoma cells in a concentration-dependent manner.3 It also inhibits tumor growth in a mouse model of Lewis lung carcinoma when administered at a dose of 0.6 μg/kg per day. | | Uses | 17(R)-Resolvin D3 is a metabolite of docosahexaenoic acid (DHA). 17(R)-Resolvin D3 has anti-inflammatory activity[1]. | | References | 1. Winkler, J.W., Uddin, J., Serhan, C.N., et al. Stereocontrolled total synthesis of the potent anti-inflammatory and pro-resolving lipid mediator resolvin D3 and its aspirin-triggered 17R-epimer Org. Lett. 15(7),1424-1427(2013).
2. Dalli, J., Winkler, J.W., Colas, R.A., et al. Resolvin D3 and aspirin-triggered resolvin D3 are potent immunoresolvents Chem. Biol. 20(2),188-201(2013).
3. Gilligan, M.M., Gartng, A., Sulcier, M.L., et al. Aspirin-triggered proresolving mediators stimulate resolution in cancer Proc. Natl. Acad. Sci. USA 116(13),6292-6297(2019). |
| | 17(R)-Resolvin D3 Preparation Products And Raw materials |
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