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| | 17(R)-Resolvin D1 methyl ester Basic information |
| Product Name: | 17(R)-Resolvin D1 methyl ester | | Synonyms: | WUKVAFWBFGABJN-PFYFFMTHSA-N;17(R)-Resolvin D1 methyl ester;4,9,11,13,15,19-Docosahexaenoic acid, 7,8,17-trihydroxy-, methyl ester, (4Z,7S,8R,9E,11E,13Z,15E,17R,19Z)- | | CAS: | 937738-64-2 | | MF: | C23H34O5 | | MW: | 390.51 | | EINECS: | | | Product Categories: | | | Mol File: | 937738-64-2.mol |  |
| | 17(R)-Resolvin D1 methyl ester Chemical Properties |
| Boiling point | 562.1±50.0 °C(Predicted) | | density | 1.064±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; Ethanol: 50 mg/ml; PBS (pH 7.2): 0.05 mg/ml | | pka | 13.33±0.20(Predicted) |
| | 17(R)-Resolvin D1 methyl ester Usage And Synthesis |
| Description | 17(R)-Resolvin D1 (17(R)-RvD1) is an aspirin-triggered epimer of RvD1 that reduces human polymorphonuclear leukocyte transendothelial migration, the earliest event in acute inflammation, with equipotency to RvD1 (EC50 = ~30 nM). 17(R)-RvD1 exhibits a dose-dependent reduction in leukocyte infiltration in a mouse model of peritonitis with maximal inhibition of ~35% at a 100 ng dose. In contrast to RvD1, the aspirin-triggered form resists rapid inactivation by eicosanoid oxidoreductases. 17(R)-RvD1 methyl ester is a methyl ester version of the free acid which may act as a lipophilic prodrug form that will alter its distribution and pharmacokinetic properties. The methyl ester moiety is susceptible to cleavage by intracellular esterases, leaving the free acid. | | Uses | 17(R)-Resolvin D1 methyl ester is the methyl ester of Resolvin D1 (RvD1) (HY-125527) induced by Aspirin (HY-14654) with the 17R epimer (AT-RvD1). RvD is a regulator of transendothelial migration of human polymorphonuclear leukocytes and an anti-inflammatory agent. The 17R-trihydroxy-4Z of RvD1 also blocks transendothelial migration of human neutrophils (EC50 approximately 30 nM). AT-RvD1 is an effective form that protects against the rapid inactivation of Resolvin D1[1]. | | References | [1] Sun YP, et al. Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, anti-inflammatory properties, and enzymatic inactivation. J Biol Chem. 2007 Mar 30;282(13):9323-9334. DOI:10.1074/jbc.M609212200 |
| | 17(R)-Resolvin D1 methyl ester Preparation Products And Raw materials |
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