tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate

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tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate manufacturers

  • Autogramin-2
  • Autogramin-2 pictures
  • $38.00
  • 2026-07-14
  • CAS:2375541-45-8
  • Purity: 96.25%
  • Supply Ability: 10g
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Basic information
Product Name:tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate
Synonyms:tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate;187407;Autogramin-2;Thiazolo[5,4-c]pyridine-5(4H)-carboxylic acid, 6,7-dihydro-2-[[4-(1-methylethoxy)benzoyl]amino]-, 1,1-dimethylethyl ester;Autogramin-2,Inhibitor,inhibit,Autogramin2,Autophagy,Autogramin 2;Autogramin-2, 10 mM in DMSO
CAS:2375541-45-8
MF:C21H27N3O4S
MW:417.52
EINECS:
Product Categories:
Mol File:2375541-45-8.mol
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Structure
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Chemical Properties
density 1.252±0.06 g/cm3(Predicted)
storage temp. -20°C
solubility Soluble in DMSO (up t0 25 mg/ml) or in Ethanol (up to 25 mg/ml)
form solid
pka7.59±0.20(Predicted)
color Off-white
Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Safety Information
MSDS Information
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Usage And Synthesis
DescriptionAutogramin-2 (2375541-45-8) is an inhibitor of autophagy (autophagy induced by amino acid starvation IC50 = 270 nM; Rapamycin IC50 = 140 nM) acting via selective targeting of the cholesterol transfer protein GRAM domain-containing protein 1A (GRAMD1A). Autogramin-2 inhibition of GRAMD1A inhibits biogenesis of the autophagosome.
UsesAutogramin-2 potently inhibits autophagy induced by either starvation (IC50=0.27 μM) or mTORC1 inhibition (Rapamycin; IC50=0.14 μM)[1].
References1.Laraia et al. (2019), The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis; Chem. Biol., 15 710
tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate Preparation Products And Raw materials
Tag:tert-butyl 2-(4-isopropoxybenzamido)-6,7-dihydrothiazolo[5,4-c]pyridine-5(4H)-carboxylate(2375541-45-8) Related Product Information
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