MBM-17

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Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Company Name: Sichuan Wei Keqi Biological Technology Co., Ltd.  
Tel: 028-81700200 18116577057
Email: 3003855609@qq.com
Company Name: Fan De(Beijing) Biotechnology Co., Ltd.  
Tel: 15911056312
Email: liming@bio-fount.com
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn

MBM-17 manufacturers

  • MBM-17
  • MBM-17 pictures
  • $1670.00
  • 2026-04-21
  • CAS:2083621-90-1
  • Purity:
  • Supply Ability: 10g
  • MBM-17
  • MBM-17 pictures
  • $1670.00
  • 2025-07-28
  • CAS:2083621-90-1
  • Purity:
  • Supply Ability: 10g
MBM-17 Basic information
Product Name:MBM-17
Synonyms:MBM-17;Benzamide, 4-[7-[1-[2-(dimethylamino)ethyl]-1H-pyrazol-4-yl]imidazo[1,2-a]pyridin-3-yl]-2-(phenylmethoxy)-;MBM 17,MBM17
CAS:2083621-90-1
MF:C28H28N6O2
MW:480.56
EINECS:
Product Categories:
Mol File:2083621-90-1.mol
MBM-17 Structure
MBM-17 Chemical Properties
density 1.26±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka15.43±0.50(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
MBM-17 Usage And Synthesis
UsesMBM-17 is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM. It effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis. MBM-55 shows antitumor activities, and no obvious toxicity to mice[1].
in vivo

MBM-17 (20 mg/kg; i.p.; twice a day for 21 days) exhibits good antitumor activity and a well-tolerated dose schedule[1].
MBM-17 (1.0 mg/kg; i.v.) treatment shows CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 42.4 mL/min/kg, 4.06 L/kg, 2.42 hours, 386 ng/h/mL, and 405 ng/h/mL, respectively[1].

Animal Model:Female BALB/c nu/nu mice (5-6 weeks, bearing HCT-116 xenografts)[1]
Dosage:20 mg/kg
Administration:Intraperitoneal injection; twice a day for 21 days
Result:Tmor growth was significantly suppressed.
Animal Model:Male Sprague Dawley (SD) rats[1]
Dosage:1.0 mg/kg
Administration:IV injection (Pharmacokinetic Analysis)
Result:The CL, Vss, T1/2, AUC0-t, and AUC0-∞ values of 42.4 mL/min/kg, 4.06 L/kg, 2.42 hours, 386 ng/h/mL, and 405 ng/h/mL, respectively.
IC 50NEK2: 3 nM (IC50)
References[1] Xi JB, et al. Structure-based design and synthesis of imidazo[1,2-a]pyridine derivatives as novel and potent Nek2 inhibitors with in vitro and in vivo antitumor activities. Eur J Med Chem. 2017 Jan 27;126:1083-1106. DOI:10.1016/j.ejmech.2016.12.026
MBM-17 Preparation Products And Raw materials
Tag:MBM-17(2083621-90-1) Related Product Information
MBM-55 MBM-17S MBM-55S MBM-17 Ruxolitinib Carbonyl cyanide 3-chlorophenylhydrazone