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| | DOTA di(tBu)ester Basic information |
| Product Name: | DOTA di(tBu)ester | | Synonyms: | DOTA di(tBu)ester;1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,7-bis(1,1-dimethylethyl) ester;Zaterol impurity 3;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate;Gadobutrol Impurity 91;DOTA-bis(tert-butyl)ester;1,7-Bis(1,1-dimethylethyl) 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate
or
DOTA-bis(tert-butyl)ester;Gadobutrol Impurity 243 | | CAS: | 913542-71-9 | | MF: | C24H44N4O8 | | MW: | 516.63 | | EINECS: | | | Product Categories: | | | Mol File: | 913542-71-9.mol |  |
| | DOTA di(tBu)ester Chemical Properties |
| Boiling point | 644.7±55.0 °C(Predicted) | | density | 1.133±0.06 g/cm3(Predicted) | | pka | 3.94±0.10(Predicted) |
| | DOTA di(tBu)ester Usage And Synthesis |
| Uses | DOTA-bis(tert-butyl)ester is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide conjugates (RDCs). DOTA-bis(tert-butyl)ester can be conjugated with different salts to form different metal chelators, such as (HY-B1244) hydrochloride to obtain DOTA-MN2. DOTA-MN2 can be reacted with [67]Ga-citrate to obtain radiolabeling. When (67)Ga-DOTA-MN2 is incubated in phosphate buffer solution or mouse plasma for 24 hours, it does not undergo significant decomposition. In the biodistribution experiment of NFSa tumor mice, it has high tumor uptake and rapid plasma clearance, and is a good material for SPECT and PET studies. | | IC 50 | RDC Bifunctional Chelator |
| | DOTA di(tBu)ester Preparation Products And Raw materials |
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