VH 032 phenol-linker 2 manufacturers
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| | VH 032 phenol-linker 2 Basic information |
| Product Name: | VH 032 phenol-linker 2 | | Synonyms: | VH 032 phenol-linker 2;VH 032 phenol-alkylC6-amine;(S,R,S)-AHPC-phenol-alkylC6-amine (dihydrochloride);(2S,4R)-1-((S)-2-Acetamido-3,3-dimethylbutanoyl)-N-(2-((6-aminohexyl)oxy)-4-(4-methylthiazol-5-yl)benzyl)-4-hydroxypyrrolidine-2-carboxamide dihydrochloride;(2S,4R)-1-[(S)-2-Acetamido-3,3-dimethylbutanoyl]-N-[2-[(6-aminohexyl)oxy]-4-(4-methyl-5-thiazolyl)benzyl]-4-hydroxypyrrolidine-2-carboxamide Dihydrochloride | | CAS: | 2376990-28-0 | | MF: | C30H46ClN5O5S | | MW: | 624.24 | | EINECS: | | | Product Categories: | | | Mol File: | 2376990-28-0.mol |  |
| | VH 032 phenol-linker 2 Chemical Properties |
| storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | Solid | | color | Light yellow to yellow |
| | VH 032 phenol-linker 2 Usage And Synthesis |
| Uses | (S,R,S)-AHPC-phenol-alkylC6-amine dihydrochloride is a synthesizedE3 ligase ligand-linker conjugatethat incorporates the VH032 based VHL ligand and an alkyl linker used forPROTAC degrader[1]. | | storage | Store at -20°C | | References | [1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | VH 032 phenol-linker 2 Preparation Products And Raw materials |
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