| Company Name: |
BOC Sciences |
| Tel: |
+1-631-485-4226 |
| Email: |
inquiry@bocsci.com |
FINO2 manufacturers
- FINO2
-
- $52.00
-
2026-07-15
- CAS:869298-31-7
- Purity: 97.27%
- Supply Ability: 10g
|
| Product Name: | FINO2 | | Synonyms: | FINO2;1,2-Dioxaspiro[4.5]decane-3-ethanol, 8-(1,1-dimethylethyl)-3-methyl-, (5α,8α)-;(5α,8α)-8-(1,1-dimethylethyl)-3-methyl-1,2-dioxaspiro[4.5]decane-3-ethanol | | CAS: | 869298-31-7 | | MF: | C15H28O3 | | MW: | 256.38 | | EINECS: | | | Product Categories: | | | Mol File: | 869298-31-7.mol |  |
| | FINO2 Chemical Properties |
| Melting point | 79-81 °C | | Boiling point | 323.8±11.0 °C(Predicted) | | density | 1.02±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS (pH 7.2) (1:2): 0.3 mg/ml | | form | A solid | | pka | 14.90±0.10(Predicted) | | color | White to off-white |
| | FINO2 Usage And Synthesis |
| Uses | FINO2 is a potent ferroptosis inducer. FINO2 inhibits GPX4 activity. FINO2 is a stable oxidant that oxidizes ferrous iron and stable at varying pH levels. FINO2 causes widespread lipid peroxidation[1]. | | Definition | ChEBI: FINO2 is an oxaspiro compound that is 1,2-dioxaspiro[4.5]decane substituted by methyl, 2-hydroxyethyl and tert-butyl groups at positions 3, 3 and 8, respectivey (the 5s,8s-stereoisomer). It induces ferroptosis in cancer cells by indirectly inhibiting glutathione peroxidase 4 (GPX4) enzymatic function and directly oxidizes iron leading to widespread lipid peroxidation. It has a role as a ferroptosis inducer and an antineoplastic agent. It is an oxaspiro compound, an organic peroxide, a primary alcohol and an organic heterobicyclic compound. | | References | [1] Gaschler MM, et al. FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation. Nat Chem Biol. 2018 May;14(5):507-515. DOI:10.1038/s41589-018-0031-6 |
| | FINO2 Preparation Products And Raw materials |
|