- 2,4-Difluorophenylacetic acid
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- $5.00 / 1KG
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2025-09-25
- CAS:81228-09-3
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: g-kg-tons, free sample is available
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| | 2,4-Difluorophenylacetic acid Basic information |
| Product Name: | 2,4-Difluorophenylacetic acid | | Synonyms: | 2,4-DIFLUOROPHENYLACETIC ACID;Benzeneacetic acid, 2,4-difluoro-;RARECHEM AL BO 0247;2,4-Difluorophenylaceticacid,99%;2,4-Difluorophenylacetic acid 97%;2,4-Difluorophenylaceticacid97%;2-(2,4-DIFLUOROPHENYL)ACETATE;2-(2,4-difluorophenyl)acetic acid | | CAS: | 81228-09-3 | | MF: | C8H6F2O2 | | MW: | 172.13 | | EINECS: | 279-709-4 | | Product Categories: | Fluorine series;Phenylacetic acid;Miscellaneous;C8;Carbonyl Compounds;Carboxylic Acids;Aromatic Phenylacetic Acids and Derivatives;Phenylacetic acid series | | Mol File: | 81228-09-3.mol |  |
| | 2,4-Difluorophenylacetic acid Chemical Properties |
| Melting point | 115-118 °C (lit.) | | Boiling point | 219°C (rough estimate) | | density | 1.3010 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 3.98±0.10(Predicted) | | form | Powder | | color | White | | BRN | 3649727 | | InChI | InChI=1S/C8H6F2O2/c9-6-2-1-5(3-8(11)12)7(10)4-6/h1-2,4H,3H2,(H,11,12) | | InChIKey | QPKZIGHNRLZBCL-UHFFFAOYSA-N | | SMILES | C1(CC(O)=O)=CC=C(F)C=C1F | | CAS DataBase Reference | 81228-09-3(CAS DataBase Reference) | | NIST Chemistry Reference | 2,4-Difluorophenylacetic acid(81228-09-3) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29163990 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 2,4-Difluorophenylacetic acid Usage And Synthesis |
| Chemical Properties | white powder | | Uses | 2,4-Difluorophenylacetic acid is used in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA). | | Uses | 2,4-Difluorophenylacetic acid has been used in the synthesis of nonpolar peptide nucleic acid monomers containing fluoroaromatics (F-PNA). | | Synthesis | (a) 25.7 g of 2,4-difluorobenzyl bromide was dissolved in 100 mL of tetrahydrofuran and slowly added dropwise over 0.5 h to a stirred suspension containing 3.0 g of magnesium chips and 30 mL of tetrahydrofuran. After the dropwise addition was completed, stirring of the reaction mixture was continued for 10 minutes. Subsequently, a steady stream of carbon dioxide was continuously passed into the resulting Grignard reagent for 1 hour. After completion of the reaction, the mixture was evaporated to dryness and the residue was partitioned with ether and dilute hydrochloric acid. The ether phase was separated and extracted with 2 N sodium hydroxide solution. The basic extract was acidified with concentrated hydrochloric acid and extracted with ether to give 5.1 g (24% yield) of crude 2,4-difluorophenylacetic acid. The crude product was dissolved directly in 25 mL of tetrahydrofuran without further purification and added slowly dropwise to a stirred mixture of 2.0 g of lithium aluminum hydride suspended in 100 mL of tetrahydrofuran. | | References | [1] Patent: US4649160, 1987, A |
| | 2,4-Difluorophenylacetic acid Preparation Products And Raw materials |
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