8-溴代鸟苷-3',5'-环状单磷酸酯钠盐
| 中文名称 | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 |
|---|---|
| 中文同义词 | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐;化合物 T14064;8-溴鸟嘌呤3',5'-环一磷酸 钠盐;8-溴-CGMP钠;8-BR-CGMP (8-BROMO-CGMP),PKG活化剂;8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 |
| 英文名称 | 8-BROMOGUANOSINE 3',5'-(CYCLIC) MONOPHOSPHATESODIUM SALT N-HYDRATE |
| 英文同义词 | 8-bromoguanosine-3’,5’-cyclicmonophosphate(8-br-cgmp),sodiumsalt,;8-bromoguanosine 3:5-cyclic*monophosphate sodiu;8-Bromoguanosine-3,5-cyclomonophosphate sodium salt;Guanosine, 8-bromo-, cyclic 3',5'-(hydrogen phosphate), monosodium salt;8-BROMOGUANOSINE 3':5'-CYCLICMONOPHOSPHA TE SODIUM;8-BROMO-CGMP SODIUM SALT 8-BROMOGUANOSIN E-3',5;GUANOSINE 3',5'-CYCLIC MONOPHOSPHATE, 8-BROMO-, SODIUM SALT;BR-CGMP, NA |
| CAS号 | 51116-01-9 |
| 分子式 | C10H12BrN5NaO7P |
| 分子量 | 448.1 |
| EINECS号 | 256-993-8 |
| 相关类别 | Cyclic Nucleotide related;Cyclic Nucleotide Metabolism;Cyclic Nucleotides and AnalogsSerine/Threonine Kinase Biology;G Proteins and Cyclic Nucleotides;Protein Kinase G (PKG);Serine/Threonine Kinase Activators |
| Mol文件 | 51116-01-9.mol |
| 结构式 |  |
8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 性质
| 储存条件 | -20°C |
|---|---|
| 溶解度 | H2O:100 mg/mL |
| 形态 | 粉末 |
| 颜色 | 白色至米白色 |
| 水溶解性 | Soluble to 100 mM in water |
| InChIKey | ZJRFCXHKYQVNFK-YEOHUATISA-M |
| SMILES | [Na+].NC1=Nc2c(nc(Br)n2[C@@H]3O[C@@H]4COP([O-])(=O)O[C@H]4[C@H]3O)C(=O)N1 |
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Ca 2+
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8-Bromo-cGMP sodium (1-100 μM; 8 h) increases resistance of LLC-PK1 cells to CsA toxicity concentration-dependently.
8-Bromo-cGMP sodium (1-100 μM; 16 h) induces the synthesis of HO-1 protein in a concentration-dependent fashion.
Cell Viability Assay
| Cell Line: | LLC-PK1 cells (ATCC CL 101) |
| Concentration: | 1-100 μM |
| Incubation Time: | 8 hours |
| Result: | Increased resistance of LLC-PK1 cells to Cyclosporin A (CsA) toxicity concentration-dependently and augmented cell viability by up to 65%. |
Western Blot Analysis
| Cell Line: | LLC-PK1 cells (ATCC CL 101) |
| Concentration: | 1-100 μM |
| Incubation Time: | 16 hours |
| Result: | Induced the synthesis of HO-1 protein in a concentration-dependent fashion. |
8-Bromo-cGMP sodium (0.3, 1, 3.0 nmol; intrathecal administration; 10 min before test) dose-dependently and significantly increases the tail-flick latency in Vincristine-treated mice to the level observed in vehicle-treated naive mice (male ICR mice, 4weeks of age and weighing 20 g). Vincristine (0.05 mg/kg 1 day after the pre-drug tail-flick latency, and then 0.125 mg/kg twice a week for 6 weeks) can induce painful neuropathy in mice.
8-Bromo-cGMP sodium (10 mg/kg; iv; single dose) results in vasodilator responses in eNOS-Tg mice and WT littermates in C57BL/6 background (19-35 g).
安全信息
| WGK Germany | 3 |
|---|---|
| F | 10-21 |
| 海关编码 | 29349990 |
| 存储类别 | 11 - 可燃固体 |
| 提供商 | 语言 |
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英文
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| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101379A | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 8-Bromo-cGMP sodium | 51116-01-9 | 5mg | 700元 |
| 2026/06/05 | HY-101379A | 8-溴代鸟苷-3',5'-环状单磷酸酯钠盐 8-Bromo-cGMP sodium | 51116-01-9 | 10mM * 1mLin Water | 770元 |