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| | 1-Aminohydantoin hydrochloride Basic information |
| | 1-Aminohydantoin hydrochloride Chemical Properties |
| Melting point | 201-205 °C(lit.) | | storage temp. | Inert atmosphere,Room Temperature | | solubility | DMSO (Slightly), Methanol (Slightly, Heated) | | form | Crystalline Powder | | color | Pale yellow | | biological source | mouse | | BRN | 3699376 | | Stability: | Unstable in Solution | | Major Application | forensics and toxicology
pharmaceutical (small molecule) | | InChI | 1S/C3H5N3O2.ClH/c4-6-1-2(7)5-3(6)8;/h1,4H2,(H,5,7,8);1H | | InChIKey | WEOHANUVLKERQI-UHFFFAOYSA-N | | SMILES | Cl[H].NN1CC(=O)NC1=O | | CAS DataBase Reference | 2827-56-7(CAS DataBase Reference) |
| Hazard Codes | Xn | | Risk Statements | 20/21/22-36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | HS Code | 29332100 | | Storage Class | 11 - Combustible Solids |
| | 1-Aminohydantoin hydrochloride Usage And Synthesis |
| Chemical Properties | Pale Yellow Powder | | Uses | A metabolite of Nitrofuran. | | Uses | Reactant for synthesis of: Ectoparasiticidal drugs1 Skeletal muscle relaxants2Reactant for: Suzuki-Miyaura coupling3 Lymphoid specific tryosine phosphatase inhibitor4 Proteasome inhibition by peptide semicarbazones5 | | Uses | 1-Aminohydantoin hydrochloride may be used as one of the reactants in the synthesis of (E)-1-(2-hydroxybenzylideneamino)imidazolidine-2,4-dione, dantrolene and dantrolene sodium. | | Biological Activity | Tumor Necrosis Factor (TNF)-Related Apoptosis-Inducing Ligand (TRAIL) activates the extrinsic apoptotic pathway by binding death receptors (DR) 4 and 5. In addition to DR 4 and 5, TRAIL activates several other receptors such as decoy receptor (DcR)1, DcR2 and a soluble receptor called osteoprotegerin. TRAIL plays a vital role in the inhibition of autoimmune inflammation and cell cycle progression. TRAIL selectively kills tumor cells without damaging normal tissues and therefore, it might act as a tumor-selective anticancer agent. TRAIL-induced apoptosis is involved in various cellular processes including activation-induced cell death, homeostasis, intrathymic negative selection, autoimmunity suppression, and immune surveillance. Repeated dosage of recombinant soluble TRAIL triggers apoptosis, inhibits tumor progression, and increases viability of mice suffering from cancer. |
| | 1-Aminohydantoin hydrochloride Preparation Products And Raw materials |
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