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Sigma-Aldrich |
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| | BMY 45778 Basic information |
| Product Name: | BMY 45778 | | Synonyms: | [3-(4,5-DIPHENYL[2,4'-BIOXAZOL]-5'-YL)PHENOXY]ACETIC ACID;BMY 45778;Acetic acid, 2-[3-(4,5-diphenyl[2,4'-bioxazol]-5'-yl)phenoxy]-;BMY 45778 >=98% (HPLC) | | CAS: | 152575-66-1 | | MF: | C26H18N2O5 | | MW: | 438.43 | | EINECS: | | | Product Categories: | | | Mol File: | 152575-66-1.mol |  |
| | BMY 45778 Chemical Properties |
| Boiling point | 659.9±65.0 °C(Predicted) | | density | 1.298±0.06 g/cm3(Predicted) | | storage temp. | room temp | | solubility | ≥67.6 mg/mL in DMSO | | form | powder | | pka | 3.10±0.10(Predicted) | | color | white to beige | | InChI | 1S/C26H18N2O5/c29-21(30)15-31-20-13-7-12-19(14-20)24-23(27-16-32-24)26-28-22(17-8-3-1-4-9-17)25(33-26)18-10-5-2-6-11-18/h1-14,16H,15H2,(H,29,30) | | InChIKey | DSRSEEYZGWTODH-UHFFFAOYSA-N |
| WGK Germany | WGK 3 | | Storage Class | 13 - Non Combustible Solids |
| | BMY 45778 Usage And Synthesis |
| Uses | BMY 45778 is an agonist for IP receptor to up-regulate the expression of C/EBPβ and C/EBPδ. | | Definition | ChEBI: BMY 45778 is a bisoxazole. It has a role as a partial prostacyclin agonist. | | Biological Activity | Non-prostanoid prostacyclin mimetic that acts as a partial agonist at IP 1 prostacyclin receptors. Potently inhibits platelet aggregation in vitro (IC 50 = 27-35 nM). | | Biochem/physiol Actions | BMY 45778 is a non-prostanoid prostacyclin agonist. | | references | [1]. seiler sm, brassard cl, federici me, et al. [3-[4-(4,5-diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic acid (bmy 45778) is a potent non-prostanoid prostacyclin partial agonist: effects on platelet aggregation, adenylyl cyclase, camp levels, protein kinase, and iloprost binding. prostaglandins, 1997, 53(1): 21-35.
[2]. wise h, qian ym, jones rl. a study of prostacyclin mimetics distinguishes neuronal from neutrophil ip receptors. eur j pharmacol, 1995, 278(3): 265-269. |
| | BMY 45778 Preparation Products And Raw materials |
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