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| | 5-Amino-4-fluoro-2-methylphenol Basic information |
| | 5-Amino-4-fluoro-2-methylphenol Chemical Properties |
| Melting point | 147 °C | | Boiling point | 271.0±35.0 °C(Predicted) | | density | 1.275±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | form | crystalline powder | | pka | 10.39±0.23(Predicted) | | color | Reddish light brown |
| | 5-Amino-4-fluoro-2-methylphenol Usage And Synthesis |
| Synthesis | General procedure: a mixture of 4-fluoro-2-methyl-5-nitrophenol (1.4 g, 8.2 mmol) and 10% Pd/C (0.3 g, 20% w/w) in methanol (80 mL) was stirred for 2 hours under hydrogen atmosphere (30 psi). Upon completion of the reaction, the Pd/C catalyst was removed by filtration and the filtrate was concentrated to afford 5-amino-4-fluoro-2-methylphenol (0.68 g, 62% yield). The product was characterized by 1H NMR (300 MHz, DMSO-d6): δ 8.75 (s, 1H), 6.62 (d, J = 12.0 Hz, 1H), 6.21 (d, J = 8.1 Hz, 1H), 4.69 (s, 2H), 1.93 (s, 3H). | | References | [1] Patent: WO2010/51373, 2010, A1. Location in patent: Page/Page column 69-70
[2] Journal of Medicinal Chemistry, 1999, vol. 42, # 26, p. 5369 - 5389
[3] Patent: US6362336, 2002, B1. Location in patent: Example 13 |
| | 5-Amino-4-fluoro-2-methylphenol Preparation Products And Raw materials |
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