化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER
| 中文名称 | 化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER |
|---|---|
| 中文同义词 | 化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER |
| 英文名称 | 2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)- |
| 英文同义词 | 2-Propenoic acid, 3-(3,4,5-trihydroxyphenyl)-, decyl ester, (2E)- |
| CAS号 | 1770778-45-4 |
| 分子式 | C19H28O5 |
| 分子量 | 336.42 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 1770778-45-4.mol |
| 结构式 |  |
化合物 3,4,5-TRIHYDROXYCINNAMIC ACID DECYL ESTER 性质
| 沸点 | 514.2±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.143±0.06 g/cm3(Predicted) |
| 储存条件 | Store at -20°C |
| 溶解度 | 二甲基亚砜：100 mg/mL（297.25 mM） |
| 形态 | 固体 |
| 酸度系数(pKa) | 8.82±0.15(Predicted) |
| 颜色 | 白色至米白色 |
3,4,5-Trihydroxycinnamic acid decyl ester 是一种高效的脂质吸收和积累抑制剂，具有抗肥胖作用。3,4,5-Trihydroxycinnamic acid decyl ester 是一种胰腺脂肪酶 (pancreatic lipase) 抑制剂，其 EC50 大约为 0.9 μM。
EC50: 0.9 μM (pancreatic lipase)
3,4,5-Trihydroxycinnamic acid decyl ester (30 μM) exhibits an inhibitory potency of approximately 92% for pancreatic lipase in vitro.
3,4,5-Trihydroxycinnamic acid decyl ester (0.1-40 μM) inhibits pancreatic lipase activity in dose-dependent manner, with an EC
50
value being approximately 0.9 μM.
3,4,5-Trihydroxycinnamic acid decyl ester inhibits pancreatic lipase in vitro and lipid accumulation during 3T3-L1 cell differentiation.
3,4,5-Trihydroxycinnamic acid decyl ester (30-150 mg/kg; p.o.) suppresses a rise in blood triglyceride (TG) levels in mice given corn oil orally.
| Animal Model: | 6 weeks old Male ddY mice |
| Dosage: | 30 mg/kg, 150 mg/kg |
| Administration: | Oral administration |
| Result: | Reduced plasma TG in a dose-dependent manner. |