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T&W GROUP |
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| | 2'-MECCPA Basic information |
| Product Name: | 2'-MECCPA | | Synonyms: | -MeCCPA;2'-Chloro-N6-cyclopentyl-2'-methyl adenosine;Adenosine, 2-chloro-N-cyclopentyl-2'-C-methyl-;2' MeCCPA,2'MeCCPA;2'-MeCCPA;2-Chloro-N-cyclopentyl-2'-Methyladenosine;2''-MeCCPA;2-Chloro-N-cyclopentyl-2′-C-methyladenosine | | CAS: | 205171-12-6 | | MF: | C16H22ClN5O4 | | MW: | 383.83 | | EINECS: | | | Product Categories: | | | Mol File: | 205171-12-6.mol |  |
| | 2'-MECCPA Chemical Properties |
| Boiling point | 643.3±65.0 °C(Predicted) | | density | 1.76±0.1 g/cm3(Predicted) | | storage temp. | Store at +4°C | | solubility | Soluble to 25 mM in DMSO | | form | Powder | | pka | 13.13±0.70(Predicted) | | color | Off-white to light yellow | | InChI | 1S/C16H22ClN5O4/c1-16(25)11(24)9(6-23)26-14(16)22-7-18-10-12(19-8-4-2-3-5-8)20-15(17)21-13(10)22/h7-9,11,14,23-25H,2-6H2,1H3,(H,19,20,21) | | InChIKey | MMPAUXMIDJWGFO-UHFFFAOYSA-N | | SMILES | Clc1nc2[n](cnc2c(n1)NC4CCCC4)C3OC(C(C3(O)C)O)CO |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 2'-MECCPA Usage And Synthesis |
| Uses | 2''-MeCCPA is an inhibitor of forskolin-stimulated adenylyl cyclase. It is also a selective A1 adenosine receptor agonist. | | Definition | ChEBI: 2-[2-chloro-6-(cyclopentylamino)-9-purinyl]-5-(hydroxymethyl)-3-methyloxolane-3,4-diol is a purine nucleoside. | | Biological Activity | Potent and highly selective agonist at A 1 adenosine receptors (K i values are 3.3, 9580, 37600 and 1150 nM for human recombinant A 1 , A 2A , A 2B and A 3 receptors respectively). Acts as a full agonist; inhibits forskolin-stimulated adenylyl cyclase activity in rat cortical membranes with an IC 50 value of 13.1 nM. | | in vivo | 2’-MeCCPA (1 nM-1 M) at reperfusion significantly reduces infarct size to risk ratio in male Sprague-Dawley rats[1]. | | IC 50 | A1AR | | storage | Store at +4°C |
| | 2'-MECCPA Preparation Products And Raw materials |
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