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1-Pentyl-3-(1-naphthoyl)indole

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1-Pentyl-3-(1-naphthoyl)indole Basic information
Product Name:1-Pentyl-3-(1-naphthoyl)indole
Synonyms:1-Pentyl-3-(1-naphthoyl)indole;1-Naphthyl-(1-pentylindol-3-yl)Methanone;JWH-018 (Spice Cannabinoid);JWH 018 (solution);Naphthalen-1-yl(1-Pentyl-1H-Indol-3-yl)Methanone;JWH -018;1-Naphthalenyl-(1-pentyl-1H-indol-3-yl)methanone;(1-Pentyl-1H-indol-3-yl)-1-naphthalenylmethanone
CAS:209414-07-3
MF:C24H23NO
MW:341.45
EINECS:635-711-0
Product Categories:Chemical for Research;Research Chemical;Aromatics;Heterocycles;Indole Derivatives;Intermediates & Fine Chemicals;Pharmaceuticals;pharmaceutical intermediate and medicine grade;intermediate
Mol File:209414-07-3.mol
1-Pentyl-3-(1-naphthoyl)indole Structure
1-Pentyl-3-(1-naphthoyl)indole Chemical Properties
Melting point 55-59°C
Boiling point 534.2±23.0 °C(Predicted)
density 1.09±0.1 g/cm3(Predicted)
Fp 9℃
storage temp. Desiccate at -20°C
solubility DMF: 10 mg/ml; DMSO: 10 mg/ml; Ethanol: 10 mg/ml; Methanol: 30 mg/ml
form A neat solid
color white to beige
InChI1S/C24H23NO/c1-2-3-8-16-25-17-22(20-13-6-7-15-23(20)25)24(26)21-14-9-11-18-10-4-5-12-19(18)21/h4-7,9-15,17H,2-3,8,16H2,1H3
InChIKeyJDNLPKCAXICMBW-UHFFFAOYSA-N
SMILESO=C(C1=CN(CCCCC)C2=C1C=CC=C2)C3=CC=CC4=C3C=CC=C4
Safety Information
Hazard Codes F,T
Risk Statements 11-23/24/25-39/23/24/25-25
Safety Statements 7-16-36/37-45
RIDADR UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 1
Storage Class11 - Combustible Solids
Hazard ClassificationsSTOT SE 3
Hazardous Substances Data209414-07-3(Hazardous Substances Data)
DEA Controlled SubstancesCSCN: 7118
CSA SCH: Schedule I
NARC: No
MSDS Information
1-Pentyl-3-(1-naphthoyl)indole Usage And Synthesis
DescriptionJWH 018 (CRM) (Item No. 27973) is a certified reference material categorized as a synthetic cannabinoid. It has been found in Spice/K2-type herbal blends and may have neurotoxic properties. JWH 018 is regulated as a Schedule I compound in the United States. JWH 018 (CRM) (Item No. 27973) is provided as a DEA exempt preparation. This product is intended for research and forensic applications.
Chemical PropertiesWhite Powder
UsesAnalgesic Drug
UsesJWH 018 is the 18th compound synthesized in a series of more than 470 analogs and metabolites of 9-Tetrahydro- cannabinol (THC) (T293200), the active component of marijuana. JWH 018 acts as cannabinoid receptor. Controlled substance.
DefinitionChEBI: JWH 018 is an indolecarboxamide.
Biological ActivityPotent cannabinoid receptor agonist with mild selectivity for CB 2 (K i values are 2.94 and 9.0 nM for CB 2 and CB 1 receptors respectively).
References[1] MARIE H DEVENTER. Identification and Investigation of the Intrinsic Receptor Activation Potential and Metabolization of the New Oxo-Pyridyl Synthetic Cannabinoid Receptor Agonist CH-FUBBMPDORA.[J]. Drug Testing and Analysis, 2025. DOI: 10.1002/dta.3854
[2] KATHARINA ELISABETH GRAFINGER. Systematic evaluation of a panel of 30 synthetic cannabinoid receptor agonists structurally related to MMB-4en-PICA, MDMB-4en-PINACA, ADB-4en-PINACA, and MMB-4CN-BUTINACA using a combination of binding and different CB1 receptor activation assays. Part III: The G protein pathway and critical comparison of different assays[J]. Drug Testing and Analysis, 2021, 13 7: 1412-1429. DOI: 10.1002/dta.3054
[3] ANNELIES CANNAERT. Synthesis and in Vitro Cannabinoid Receptor 1 Activity of Recently Detected Synthetic Cannabinoids 4F-MDMB-BICA, 5F-MPP-PICA, MMB-4en-PICA, CUMYL-CBMICA, ADB-BINACA, APP-BINACA, 4F-MDMB-BINACA, MDMB-4en-PINACA, A-CHMINACA, 5F-AB-P7AICA, 5F-MDMB-P7AICA, and 5F-AP7AICA[J]. ACS Chemical Neuroscience, 2020, 11 24: 4434-4446. DOI: 10.1021/acschemneuro.0c00644
1-Pentyl-3-(1-naphthoyl)indole Preparation Products And Raw materials
Tag:1-Pentyl-3-(1-naphthoyl)indole(209414-07-3) Related Product Information
Indole TERT-AMYL METHYL ETHER Cyclopentanecarbaldehyde Carbaryl Naphazoline hydrochloride Menadione sodium bisulfite null 1-Pentyl-3-(1-naphthoyl)indole 2-Chlorophenyl cyclopentyl ketone