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| | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- Basic information |
| Product Name: | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- | | Synonyms: | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-;Icapamespib (Synonyms: PU-HZ151);PU-HZ151;8-((6-Iodobenzo[d][1,3]dioxol-5-yl)thio)-9-(2-(neopentylamino)ethyl)-9H-purin-6-amine;9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-6-amine;Icapamespib;6-Amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]-9H-purine-9-ethanamine (ACI) | | CAS: | 1000999-96-1 | | MF: | C19H23IN6O2S | | MW: | 526.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1000999-96-1.mol | ![9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- Structure](CAS/20210305/GIF/1000999-96-1.gif) |
| | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- Chemical Properties |
| Boiling point | 648.4±65.0 °C(Predicted) | | density | 1.76±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | form | Solid | | pka | 9.76±0.19(Predicted) | | color | White to off-white |
| | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- Usage And Synthesis |
| Uses | Icapamespib (PU-HZ151) is a potent HSP90 inhibitor with an EC50 of 5nM. Icapamespib is able to cross blood-brain barrier[1]. | | References | [1] Bolaender A, et al. Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nat Commun. 2021;12(1):4669. Published 2021 Aug 3. DOI:10.1038/s41467-021-24821-2 |
| | 9H-Purine-9-ethanamine, 6-amino-N-(2,2-dimethylpropyl)-8-[(6-iodo-1,3-benzodioxol-5-yl)thio]- Preparation Products And Raw materials |
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