Sonrotoclax (BGB-11417)
| 中文名称 | Sonrotoclax (BGB-11417) |
|---|---|
| 中文同义词 | BENZAMIDE, N-[[4-[[(TRANS-4-HYDROXY-4-METHYLCYCLOHEXYL)METHYL]AMINO]-3-NITROPHENYL]SULFONYL]-4-[2-[(2S)-2-[2-(1-METHYLETHYL)PHENYL]-1-PYRROLIDINYL]-7-AZASPIRO[3;化合物 SONROTOCLAX;N-[[4-[[(反式-4-羟基-4-甲基环己基)甲基]氨基]-3-硝基苯基]磺酰基]-4-[2-[(2S)-2-[2-(1-甲基乙基)苯基]-1-吡咯烷基]-7-氮杂螺[3.5]壬-7-基]-2-(1H-吡咯并[2,3-B]吡啶-5-基氧基)苯甲酰胺;索托克拉;N-[[4-[[(反式-4-羟基-4-甲基环己基)甲基]氨基]-3-硝基苯基]磺酰基]-4-[2-[(2S)-2-[2-(1-Chemicalbook甲基乙基)苯基]-1-吡咯烷基]-7-氮杂螺[3.5]壬-7-基]-2-(1H-吡咯并[2,3-B]吡啶-5-基氧基)苯甲酰胺 |
| 英文名称 | Benzamide, N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[2-[(2S)-2-[2-(1-methylethyl)phenyl]-1-pyrrolidinyl]-7-azaspiro[3.5]non-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)- |
| 英文同义词 | Benzamide, N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[2-[(2S)-2-[2-(1-methylethyl)phenyl]-1-pyrrolidinyl]-7-azaspiro[3.5]non-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-;2-((1H-pyrrolo[2,3-b]pyridin-5-yl)oxy)-N-((4-((((1r,4r)-4-hydroxy-4-methylcyclohexyl)methyl)amino)-3-nitrophenyl)sulfonyl)-4-(2-((S)-2-(2-isopropylphenyl)pyrrolidin-1-yl)-7-azaspiro[3.5]nonan-7-yl)benzamide;Sonrotoclax (BGB-11417);Benzamide, N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[2-[(2S)-2-[2-(1-methylethyl)phenyl]-1-pyrrolidinyl]-7-azaspiro[3.5]non-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin;Benzamide,N-[[4-[[(trans-4-hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[2-[(2S)-2Chemicalbook-[2-(1-methylethyl)phenyl]-1-pyrrolidinyl]-7-azaspiro[3.5]non-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)-;BGB-11417;sonrotoclax;N-[[4-[[(trans-4-Hydroxy-4-methylcyclohexyl)methyl]amino]-3-nitrophenyl]sulfonyl]-4-[2-[(2S)-2-[2-(1-methylethyl)phenyl]-1-pyrrolidinyl]-7-azaspiro[3.5]non-7-yl]-2-(1H-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide (ACI) |
| CAS号 | 2383086-06-2 |
| 分子式 | C49H59N7O7S |
| 分子量 | 890.1 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 2383086-06-2.mol |
| 结构式 |  |
Sonrotoclax (BGB-11417) 性质
| 密度 | 1.38±0.1 g/cm3(Predicted) |
|---|---|
| 形态 | 固体 |
| 酸度系数(pKa) | 3.82±0.10(Predicted) |
| 颜色 | 浅黄至黄色 |
| InChIKey | ZQTKOYMWCCSKON-IOLMNHQTSA-N |
| SMILES | C(NS(C1=CC=C(NC[C@@H]2CC[C@@](O)(C)CC2)C([N+]([O-])=O)=C1)(=O)=O)(=O)C1=CC=C(N2CCC3(CC(N4CCC[C@H]4C4=CC=CC=C4C(C)C)C3)CC2)C=C1OC1=CN=C2NC=CC2=C1 |
Sonrotoclax 是一种口服有效的 Bcl2 抑制剂。Sonrotoclax 对多种淋巴瘤和白血病细胞系具有有效的细胞杀伤作用。