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| | TRIPTRIOLIDE Basic information |
| | TRIPTRIOLIDE Chemical Properties |
| | TRIPTRIOLIDE Usage And Synthesis |
| Uses | Triptriolide inhibits Puromycin aminonucleoside PAN (HY-15695)-induced apoptosis in mouse podocytes through regulation of Bcl-2 family proteins and inhibition of Caspase-3. Triptriolide promotes the cell survival, protects and restores the podocyte function through activation of TAK1-NF-κB signaling pathway and upregulation of podocin[1]. | | Definition | ChEBI: Triptriolide is an abietane diterpenoid with formula C20H26O7, originally isolated from Tripterygium wilfordii. It has a role as a plant metabolite and an anti-inflammatory agent. It is a gamma-lactone, a triol, an epoxide and an abietane diterpenoid. | | References | [1] Yang YQ, et al., Dual-function of triptriolide in podocytes injury: inhibiting of apoptosis and restoring of survival. Biomed Pharmacother. 2019 Jan;109:1932-1939. DOI:10.1016/j.biopha.2018.11.031 |
| | TRIPTRIOLIDE Preparation Products And Raw materials |
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