4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide

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4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Suppliers list
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4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Basic information
Product Name:4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide
Synonyms:4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide;7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-5,5-dioxo-4H-thieno[3,2-c]thiochromene-2-carboxamide
CAS:2595314-46-6
MF:C34H27NO5S2
MW:593.71
EINECS:
Product Categories:
Mol File:2595314-46-6.mol
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Structure
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Chemical Properties
Boiling point 907.9±65.0 °C(Predicted)
density 1.328±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 100 mg/mL (168.43 mM; Need ultrasonic)
pka12.62±0.20(Predicted)
form Solid
color Off-white to light yellow
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Usage And Synthesis
UsesWEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1].
Biological ActivityWEHI-9625 is a tricyclic sulfone, first-in-class inhibitor of apoptosis with an EC50 of 69 nM. WEHI-9625 binds to VDAC2 and promotes its ability to inhibit apoptosis driven by mouse BAK. WEHI-9625 is completely inactive against both human BAK and the closely related apoptosis effector BAX[1]. WEHI-9625 (0-10 μM; Mcl1-/-Bax-/- MEFs cells) treatment could prevent cell death mediated by BAK and potently inhibits BIM BH3-induced loss of mitochondrial membrane potential in Bax-/-, but not Bak-/-, cells[1]. WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1].
in vivo

WEHI-9625 demonstrates that blocking apoptosis at an early stage was both advantageous and pharmacologically tractable[1].

IC 50Bak; Bax
References[1]. van Delft MF, et al. A small molecule interacts with VDAC2 to block mouse BAK-driven apoptosis. Nat Chem Biol. 2019 Oct 7.
4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide Preparation Products And Raw materials
Tag:4H-Thieno[3,2-c][1]benzothiopyran-2-carboxamide, 7-[2-(4-methoxybenzoyl)phenyl]-N-[(4-methylphenyl)methyl]-, 5,5-dioxide(2595314-46-6) Related Product Information
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