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| | Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) Basic information |
| Product Name: | Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) | | Synonyms: | N-Boc-2-amino-5-methylpyrazine;2-Boc-Amino-5-methylpyrazine;tert-butyl N-(5-Methylpyrazin-2-yl)carbaMate;CarbaMic acid,N-(5-Methyl-2-pyrazinyl)-, 1,1-diMethylethyl ester;Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI);2-N-Boc-aMino-5-Methylpyrazin;1,1-diMethylethyl ester (9CI);pyrazin-2-yL | | CAS: | 369638-68-6 | | MF: | C10H15N3O2 | | MW: | 209.24 | | EINECS: | 200-589-5 | | Product Categories: | N-BOC | | Mol File: | 369638-68-6.mol |  |
| | Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) Chemical Properties |
| Boiling point | 268.8±40.0 °C(Predicted) | | density | 1.154±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 11.63±0.70(Predicted) | | Appearance | White to light yellow Solid |
| | Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) Usage And Synthesis |
| Synthesis | 5-Methylpyrazine-2-carboxylic acid (13.81 g, 0.1 mol), tert-butanol (95 mL, 1 mol), triethylamine (27.9 mL, 0.2 mol) and diphenylphosphoryl azide (30.27 g, 0.11 mol) were dissolved in 300 mL of toluene. The reaction mixture was heated to reflux temperature for 8 hours. Upon completion of the reaction, the product was purified by silica gel column chromatography with petroleum ether-ethyl acetate (20:1, v/v) as eluent to afford 15.2 g of N-Boc-2-amino-5-methylpyrazine as a pale yellow solid in 72.7% yield. | | References | [1] Bioorganic and Medicinal Chemistry Letters, 2006, vol. 16, # 14, p. 3751 - 3754
[2] Bioorganic and Medicinal Chemistry Letters, 2005, vol. 15, # 18, p. 4136 - 4142
[3] Patent: EP2781508, 2014, A1. Location in patent: Paragraph 0153
[4] Bioorganic and Medicinal Chemistry Letters, 2002, vol. 12, # 8, p. 1203 - 1208
[5] Patent: WO2011/90738, 2011, A2. Location in patent: Page/Page column 45 |
| | Carbamic acid, (5-methylpyrazinyl)-, 1,1-dimethylethyl ester (9CI) Preparation Products And Raw materials |
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