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| | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) Basic information |
| Product Name: | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) | | Synonyms: | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI);PyriMidine, 2,4-diMethyl-;2,4-DIMETHYL- (6CI,7CI,8CI,9CI);2,4-Dimethylpyrimidine | | CAS: | 14331-54-5 | | MF: | C6H8N2 | | MW: | 108.14 | | EINECS: | | | Product Categories: | PYRIMIDINE | | Mol File: | 14331-54-5.mol |  |
| | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) Chemical Properties |
| Melting point | -2°C | | Boiling point | 150.55°C | | density | 1.1680 | | refractive index | 1.4880 | | storage temp. | 2-8°C | | pka | 2.38±0.20(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 2,4-dimethylpyrimidine using 2,4-dimethylpyrimidine-5-carboxylic acid as a starting material is as follows: referring to Example 78, 2,4-dimethyl-5-pyrimidine carboxylic acid was heated and reacted at 160 °C for 4 hours. Upon completion of the reaction, the reaction mixture was distilled at atmospheric pressure and the fractions with boiling points of 152-153°C were collected to afford the target compound 2,4-dimethylpyrimidine (17 g, 49% yield). The product was characterized by 1H-NMR (CDCl3) with chemical shifts δ: 2.50 (3H, s, methyl proton), 2.70 (3H, s, methyl proton), 6.98 (1H, d, J = 5.1 Hz, pyrimidine cyclic proton), 8.49 (1H, d, J = 5.1 Hz, pyrimidine cyclic proton). | | References | [1] Journal of Heterocyclic Chemistry, 1990, vol. 27, # 2, p. 295 - 305
[2] Patent: EP1402900, 2004, A1
[3] Patent: EP1364949, 2003, A1. Location in patent: Page/Page column 100 |
| | Pyrimidine, 2,4-dimethyl- (6CI,7CI,8CI,9CI) Preparation Products And Raw materials |
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