Angiotensin I/II (5-8) manufacturers
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| | Angiotensin I/II (5-8) Basic information |
| Product Name: | Angiotensin I/II (5-8) | | Synonyms: | H-ILE-HIS-PRO-PHE-OH;ILE-HIS-PRO-PHE;IHPF;ANGIOTENSIN II (5-8);Angiotensin II (5-8) (human, rat, mouse);Angiotensin I/II (5-8) H-Ile-His-Pro-Phe-OH;(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-amino-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoicacid;L-Phenylalanine, L-isoleucyl-L-histidyl-L-prolyl- | | CAS: | 34233-50-6 | | MF: | C26H36N6O5 | | MW: | 512.6 | | EINECS: | | | Product Categories: | peptide | | Mol File: | Mol File |  |
| | Angiotensin I/II (5-8) Chemical Properties |
| Boiling point | 915.4±65.0 °C(Predicted) | | density | 1.286±0.06 g/cm3(Predicted) | | storage temp. | -15°C | | solubility | Soluble in DMSO | | pka | 3.56±0.10(Predicted) | | form | Solid | | color | White to off-white | | Sequence | H-Ile-His-Pro-Phe-OH |
| | Angiotensin I/II (5-8) Usage And Synthesis |
| Uses | Angiotensin II (5-8), human is an endogenous C-terminal fragment of the peptide vasoconstrictor angiotensin II[1]. Angiotensin II binds the AT II type 1 (AT1) receptor, stimulating GPCRs in vascular smooth muscle cells and increasing intracellular Ca2+ levels. Angiotensin II also acts at the Na+/H+ exchanger in the proximal tubules of the kidney[2][3]. | | Definition | ChEBI: Angiotensin (5-8) is a dichlorobenzene. | | References | [1] Guethe LM, et al. Angiotensin (5-8) modulates nociception at the rat periaqueductal gray via the NO-sGC pathway and an endogenous opioid. Neuroscience. 2013 Feb 12;231:315-27. DOI:10.1016/j.neuroscience.2012.11.048
[2] De Giusti VC, et al. Modulation of the cardiac sodium/bicarbonate cotransporter by the renin angiotensin aldosterone system: pathophysiological consequences. Front Physiol. 2014 Jan 17;4:411. DOI:10.3389/fphys.2013.00411
[3] Moon JY, et al. Recent Update of Renin-angiotensin-aldosterone System in the Pathogenesis of Hypertension. Electrolyte Blood Press. 2013 Dec;11(2):41-5. DOI:10.5049/EBP.2013.11.2.41 |
| | Angiotensin I/II (5-8) Preparation Products And Raw materials |
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