Adenosine, 5′-chloro-5′-deoxy-2-fluoro-

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Adenosine, 5′-chloro-5′-deoxy-2-fluoro- manufacturers

  • Fludarabine-Cl
  • Fludarabine-Cl pictures
  • $557.00
  • 2026-05-11
  • CAS:2734853-80-4
  • Purity:
  • Supply Ability: 10g
Adenosine, 5′-chloro-5′-deoxy-2-fluoro- Basic information
Product Name:Adenosine, 5′-chloro-5′-deoxy-2-fluoro-
Synonyms:Fludarabine Phosphate Impurity 35;Fludarabine-Cl;(2R,3R,4S,5S)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(chloromethyl)tetrahydrofuran-3,4-diol;(2R,3R,4S,5S)-2-(6-amino-2-fluoro-9H-purin-9-yl)-5-(chloromethyl)oxolane-3,4-diol;Nicotinamide Impurity 159;Fludarabine-Cl（ZYS-1);Adenosine, 5′-chloro-5′-deoxy-2-fluoro-;5’-Chloro-5’-deoxy-2-fluoro-adenosine
CAS:2734853-80-4
MF:C10H11ClFN5O3
MW:303.68
EINECS:
Product Categories:
Mol File:2734853-80-4.mol
Adenosine, 5′-chloro-5′-deoxy-2-fluoro- Structure
Adenosine, 5′-chloro-5′-deoxy-2-fluoro- Chemical Properties
Boiling point 711.5±70.0 °C(Predicted)
density 2.12±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
pka12.96±0.70(Predicted)
form Solid
color White to off-white
Water Solubility Water : 5 mg/mL (16.46 mM; ultrasonic and warming and heat to 60°C)
Safety Information
MSDS Information
Adenosine, 5′-chloro-5′-deoxy-2-fluoro- Usage And Synthesis
UsesFludarabine-Cl has an inhibitory effect on RNA adenosine deaminase 1 (ADAR1) with an IC50 of 0.87 μM and can be used to prevent and/or study cancer or tumor-related diseases[1].
Biological ActivityFludarabine-Cl has inhibition effect on RNA adenosine deaminase 1(ADAR1), and can be used for preventing and/or treating cancer or tumor-related diseases[1].
in vivo

Fludarabine-Cl (104.9-400 mg/kg, intraperitoneal injection, twice a day, for one day) has some toxicity in mice, with an LD50 of 186.5641 mg/kg[1].
Fludarabine-Cl (10-20 mg/kg, intraperitoneal injection, twice a day, for 29 days) inhibits tumor proliferation in mice[1].

Animal Model:ICR mice[1]
Dosage:104.9, 131.1, 163.8, 204.8, 256, 320, 400 mg/kg; twice a day; one day
Administration:Intraperitoneal injection (i.p.)
Result:Was somewhat toxic and could cause death in mice at higher doses, but no abnormality in organs.
Animal Model:BALB/c mice induced by Du-145[1]
Dosage:10, 20 mg/kg; twice a day; 29 days
Administration:Intraperitoneal injection (i.p.)
Result:Inhibited tumor growth and had no effect on mouse body weight.
IC 50ADAR1: 0.87 μM (IC50)
References[1]. Polysubstituted purine compound and preparation method and application thereof. CN113549076A.
Adenosine, 5′-chloro-5′-deoxy-2-fluoro- Preparation Products And Raw materials
Tag:Adenosine, 5′-chloro-5′-deoxy-2-fluoro-(2734853-80-4) Related Product Information
5-Oxaspiro[3.4]octane-7,8-diol, 6-(6-amino-9H-purin-9-yl)-1-(hydroxymethyl)-, (1R,4R,6R,7R,8S)- 1-(2'-deoxy-beta-threopentofuranosyl)adenine psicofuranine 9-arabinofuranosyladenine [5'-13C]2'-Deoxyadenosine monohydrate Adenosine-2'-13C