3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]-

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3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Suppliers list
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3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Basic information
Product Name:3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]-
Synonyms:3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]-;BACE1-IN-6;Compound 15
CAS:2079945-75-6
MF:C25H23F2N5O2S
MW:495.54
EINECS:
Product Categories:
Mol File:2079945-75-6.mol
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Structure
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Chemical Properties
Boiling point 713.7±70.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka4.94±0.60(Predicted)
Safety Information
MSDS Information
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Usage And Synthesis
UsesBACE1-IN-6 is a BACE1 inhibitor with an IC50 value of 1.5 nM.
References[1] Frohn M, et al. The development of a structurally distinct series of BACE1 inhibitors via the (Z)-fluoro-olefin amide bioisosteric replacement. Bioorg Med Chem Lett. 2020 Jul 15;30(14):127240. DOI:10.1016/j.bmcl.2020.127240
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Preparation Products And Raw materials
Tag:3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]-(2079945-75-6) Related Product Information
3-Pyridinecarbonitrile, 6-[(1Z)-2-[3-[(1S,5S,6S)-3-amino-5-methyl-1-(4-morpholinylcarbonyl)-2-thia-4-azabicyclo[4.1.0]hept-3-en-5-yl]-4-fluorophenyl]-1-fluoroethenyl]- Elenbecestat(E2609) 2-Pyridinecarboxamide, N-[3-[(3R,6R)-5-amino-3,6-dihydro-3,6-dimethyl-6-(trifluoromethyl)-2H-1,4-oxazin-3-yl]-4-fluorophenyl]-5-cyano-3-methyl- LY2811376 MK-8931 Dispiro[cyclohexane-1,2'-[2H]indene-1'(3'H),2''-[2H]iMidazol]-4''-aMine, 4-Methoxy-5''-Methyl-6'-[5-(1-propyn-1-yl)-3-pyridinyl]-, (1α,1'R,4β)-