2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-

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2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Basic information
Product Name:2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-
Synonyms:2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]-;Chk1-IN-6
CAS:2428423-77-0
MF:C16H18F3N7
MW:365.36
EINECS:
Product Categories:
Mol File:2428423-77-0.mol
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Structure
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Chemical Properties
Boiling point 569.9±60.0 °C(Predicted)
density 1.35±0.1 g/cm3(Predicted)
pka10.01±0.25(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Usage And Synthesis
UsesChk1-IN-6 is a potent, selective, and orally bioavailable CHK1 inhibitor candidate.
IC 50Chk1
References[1] Jin T, et al. Discovery and Development of a Potent, Selective, and Orally Bioavailable CHK1 Inhibitor Candidate: 5-((4-((3-Amino-3-methylbutyl)amino)-5-(trifluoromethyl)pyrimidin-2-yl)amino)picolinonitrile. J Med Chem. 2021 Oct 28;64(20):15069-15090. DOI:10.1021/acs.jmedchem.1c00994
2-Pyridinecarbonitrile, 5-[[4-[(3-amino-3-methylbutyl)amino]-5-(trifluoromethyl)-2-pyrimidinyl]amino]- Preparation Products And Raw materials
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