| Company Name: |
TargetMol Chemicals Inc.
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4008200310 15002144251 |
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marketing@tsbiochem.com |
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Product Name:Oxodipine
CAS:90729-41-2
Purity:99.64% Package:1mg/RMB 253;5mg/RMB 590;10mg/RMB 872
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| Company Name: |
SHAANXI DIDEU MEDICHEM CO.LTD
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029-029-81123119 17391733320 |
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1021@dideu.com |
| Products Intro: |
Product Name:5-O-ethyl 3-O-methyl 4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate
CAS:90729-41-2
Purity:98 Package:25kg
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| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
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customer_service@efebio.com |
| Products Intro: |
Product Name:Oxodipine
CAS:90729-41-2
Purity:99.00% Package:1mg;5mg;10mg
|
| Company Name: |
Shanghai Amole Biotechnology Co., Ltd.
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| Tel: |
13370042665 18916960931 |
| Email: |
2596183085@qq.com |
| Products Intro: |
Product Name:Oxodipine
CAS:90729-41-2
Purity:5mg；50mg；25mg；1mg；10mg Package:99%
|
Oxodipine manufacturers
- Oxodipine
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- $37.00
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2026-07-13
- CAS:90729-41-2
- Purity: 99.64%
- Supply Ability: 10g
|
| | Oxodipine Basic information |
| Product Name: | Oxodipine | | Synonyms: | 5-O-ethyl 3-O-methyl 4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate;Oxodipine;3,5-Pyridinedicarboxylic acid, 4-(1,3-benzodioxol-4-yl)-1,4-dihydro-2,6-dimethyl-, 3-ethyl 5-methyl ester | | CAS: | 90729-41-2 | | MF: | C19H21NO6 | | MW: | 359.37 | | EINECS: | | | Product Categories: | | | Mol File: | 90729-41-2.mol |  |
| | Oxodipine Chemical Properties |
| Boiling point | 470.0±45.0 °C(Predicted) | | density | 1.247±0.06 g/cm3(Predicted) | | pka | 2.98±0.70(Predicted) |
| | Oxodipine Usage And Synthesis |
| Uses | Oxodipine, a dihydropyridine-type calcium antagonist, inhibits KCl-induced aortic contraction in rabbits and reduces cardiac force in less potent rat ventricular test-paper contractions. In rat cultured neonatal ventricular myocytes, Oxodipine reduces L-type Ca currents (I) with an IC50 of 0.24 μM, and against T-type Ca currents (I) with an IC50 of 0.41 μM. Oxodipine causes constipation in mice and gingival hyperplasia in dogs[1][2][3][4][5][6]. | | Enzyme inhibitor | This dihydropyridine-class calcium ion blocker (FW = 359.37 g/mol; CAS 90729-41-2), also known as 4-(1,3-benzodioxol-4-yl)-2,6-dimethyl-1,4- dihydropyridine-3,5-dicarboxylic acid O3 -ethyl,O5 -methyl ester, greatly depresses KCl-induced contraction of rabbit aorta and also decreases the contractile force of rat ventricular strips, the latter with lower potency. Oxodipine markedly shortens cardiac action potentials, and, in rat cultured neonatal ventricular myocytes, oxodipine decreases the L-type Ca2+ current (ICaL) with IC50 of 0.24 μM and is also an effective blocker of T-type Ca2+ current (ICaT) than elgodipine (IC50 = 0.41 μM). | | References | [1] Nyska A, et al. Gingival hyperplasia in rats induced by oxodipine‐a calcium channel blocker[J]. Journal of Periodontal Research, 1990, 25(2): 65-68. DOI:10.1111/j.1600-0765.1990.tb00893.x
[2] Tamargo J, et al. Effects of oxodipine on 45Ca movements and contractile responses in vascular smooth muscle[J]. British journal of pharmacology, 1989, 97(2): 339. DOI:10.1111/j.1476-5381.1989.tb11959.x
[3] Galán L, et al. Characteristics of Ca2+ channel blockade by oxodipine and elgodipine in rat cardiomyocytes[J]. European journal of pharmacology, 1998, 357(1): 93-105. DOI:10.1016/s0014-2999(98)00543-3
[4] Egros F, et al. An original intragastric delivery system for oral administration of solid formulations to fully conscious rats: its application to oxodipine studies[J]. European Journal of Drug Metabolism and Pharmacokinetics, 1991: 71-76. PMID:1820939
[5] Montastruc P, et al. Effect of oxodipine, a novel dihydropyridine calcium channel blocker, in neurogenic hypertensive dogs[J]. Archives internationales de pharmacodynamie et de thérapie, 1993, 321: 57-62. PMID:8323416
[6] Tejerina T, et al. Effects of oxodipine on isolated rabbit aorta and mesenteric resistance vessels[J]. European journal of pharmacology, 1992, 219(2): 279-284. DOI:10.1016/0014-2999(92)90306-o |
| | Oxodipine Preparation Products And Raw materials |
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