4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- manufacturers
- HIF-1α-IN-2
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- $82.00
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2026-07-16
- CAS:2762315-06-8
- Purity: 99.90%
- Supply Ability: 10g
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| | 4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- Basic information |
| | 4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- Chemical Properties |
| Boiling point | 540.3±50.0 °C(Predicted) | | density | 1.257±0.06 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | pka | 8.40±0.50(Predicted) | | form | Solid | | color | Off-white to light yellow |
| | 4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- Usage And Synthesis |
| Description | HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2 suppresses HIF-1α expression by blocking transcription and protein translation[1]. HIF-1α-IN-2 (compound 7f) (5 μM; 72h) suppresses the viability of MDA-MB-231 and MiaPaCa-2 cells with IC50s of 28 nM and 15 nM, respectively[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses the expression of HIF-1α and VEGF with dose-dependent effect[1].
HIF-1α-IN-2 (0.25, 0.5, and 1 µM; 16-24h) can significantly inhibit the migration of MDA-MD-231 cells by 56% (0.25 µM), 83% (0.5 µM), and 85% (1 µM), respectively, and also noted in MiaPaCa-2 cells, which demonstrates the unique anti-migration effect of HIF-1α-IN-2[1].
HIF-1α-IN-2 (0-1 μM; 72h) suppresses HIF-1α mRNA levels in MDA-MB-231 cells under hypoxia[1]. Cell Viability Assay Cell Viability Assay | | Uses | HIF-1α-IN-2 is an effective HIF-1α inhibitor with anticancer potencies (IC50s of 28 nM and 15 nM in MDA-MB-231 and MiaPaCa-2 cells, respectively). HIF-1α-IN-2suppresses HIF-1α expression by blocking transcription andprotein translation[1]. | | References | [1] Wu YC, et al. Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors. Bioorg Chem. 2022;121:105681. DOI:10.1016/j.bioorg.2022.105681 |
| | 4-Quinolinamine, 7-methoxy-2-methyl-N-[3-(2-methyl-4-thiazolyl)phenyl]- Preparation Products And Raw materials |
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