- Brequinar sodium
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- $60.00 / 5mg
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2025-10-26
- CAS:96201-88-6
- Min. Order:
- Purity: 98.16%
- Supply Ability: 10g
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| | Bipenquinate Basic information |
| Product Name: | Bipenquinate | | Synonyms: | Bipenquinate;Brequinar sodium;2-(2'-Fluoro-1,1'-biphenyl-4-yl)-3-methyl-6-fluoroquinoline-4-carboxylic acid sodium salt;Dup-785;NSC-368390;SODIUM 6-FLUORO-2-(2-FLUORO-[1,1-BIPHENYL]-4-YL)-3-METHYLQUINOLINE-4-CARBOXYLATE;6-Fluoro-2-(2'-fluoro[1,1'-biphenyl]-4-yl)-3-methyl-4-quinolinecarboxylic acid sodium;6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylate | | CAS: | 96201-88-6 | | MF: | C23H14F2NNaO2 | | MW: | 0 | | EINECS: | 604-604-1 | | Product Categories: | | | Mol File: | 96201-88-6.mol |  |
| | Bipenquinate Chemical Properties |
| Melting point | >360° | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | solubility | Soluble in DMSO (up to at least 25 mg/ml) or in Water (up to 15 mg/ml with warming) | | form | solid | | color | Off-white or white | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20° for up to 1 month. |
| | Bipenquinate Usage And Synthesis |
| Description | Brequinar sodium (96201-88-6) is an inhibitor of dihydroorotate dehydrogenase (DHODH)1,2?with IC50’s between 0.2 and 5.8 μM in various cell lines3?and 20 nM in isolated enzyme4. It reduced leukemic cell burden, decreased levels of leukemia-initiating cells, and improved survival in human and mouse models of acute myeloid leukemia.4?Brequinar displayed broad antiviral activity against flaviviruses, positive-strand RNA alphaviruses, negative-strand RNA rhabdoviruses, Influenza A and B viruses, and HIV.5-7 | | Uses | Antineoplastic. | | Definition | ChEBI: Brequinar sodium is an organic sodium salt of brequinar. It has a role as an anticoronaviral agent, an antineoplastic agent, an antiviral agent, an EC 1.3.5.2 [dihydroorotate dehydrogenase (quinone)] inhibitor, an immunosuppressive agent, a pyrimidine synthesis inhibitor and an antimetabolite. It contains a brequinar(1-). | | storage | Store at +4°C | | References | [1] S F CHEN D L D R L Ruben. Mechanism of action of the novel anticancer agent 6-fluoro-2-(2’-fluoro-1,1’-biphenyl-4-yl)-3-methyl-4-quinolinecarbo xylic acid sodium salt (NSC 368390): inhibition of de novo pyrimidine nucleotide biosynthesis.[J]. Cancer research, 1986, 46 10: 5014-5019.
[2] G J PETERS. In vivo inhibition of the pyrimidine de novo enzyme dihydroorotic acid dehydrogenase by brequinar sodium (DUP-785; NSC 368390) in mice and patients.[J]. Cancer research, 1990, 50 15: 4644-4649.
[3] E. DE KANT. The relation between inhibition of cell growth and of dihydroorotic acid dehydrogenase by Brequinar Sodium[J]. Cancer letters, 1989, 46 2: Pages 123-127. DOI:10.1016/0304-3835(89)90019-0
[4] D. SYKES. Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia[J]. Cell, 2016, 167 1: 171-186.e15. DOI:10.1016/j.cell.2016.08.057
[5] MIN QING. Characterization of dengue virus resistance to brequinar in cell culture.[J]. Antimicrobial Agents and Chemotherapy, 2010: 3686-3695. DOI:10.1128/aac.00561-10
[6] PETTER I. ANDERSEN. Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine[J]. Viruses-Basel, 2019. DOI:10.3390/v11100964
[7] JUN-GYU PARK. Identification and Characterization of Novel Compounds with Broad-Spectrum Antiviral Activity against Influenza A and B Viruses.[J]. Journal of Virology, 2020. DOI:10.1128/jvi.02149-19 |
| | Bipenquinate Preparation Products And Raw materials |
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