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| | Esuprone Basic information |
| Product Name: | Esuprone | | Synonyms: | Esuprone;3,4-dimethyl-2-oxo-2H-1-benzopyran-7-yl ethanesulfonate;LU 43839;LU43839;LU-43839;Esuprone, 10 mM in DMSO | | CAS: | 91406-11-0 | | MF: | C13H14O5S | | MW: | 282.315 | | EINECS: | | | Product Categories: | | | Mol File: | 91406-11-0.mol |  |
| | Esuprone Chemical Properties |
| | Esuprone Usage And Synthesis |
| Uses | Esuprone is a brain-penetrant, orally active and selective MAO A inhibitor with an IC50 of 7.3 nM. Esuprone can be used for neurological research[1][2]. | | in vivo | Esuprone (20 mg/kg, p.o., 2 h) significantly increased afterdischarge threshold (ADT) in rats by 130% above control[1].
| | IC 50 | MAO-A: 7.3 nM (IC50) | | References | [1] Lscher W, et al. Inhibition of monoamine oxidase type A, but not type B, is an effective means of inducing anticonvulsant activity in the kindling model of epilepsy. J Pharmacol Exp Ther. 1999 Mar;288(3):984-92. PMID:10027835
[2] Bergstrm M, et al. MAO-A inhibition in brain after dosing with esuprone, moclobemide and placebo in healthy volunteers: in vivo studies with positron emission tomography. Eur J Clin Pharmacol. 1997;52(2):121-8. DOI:10.1007/s002280050260 |
| | Esuprone Preparation Products And Raw materials |
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