ALPHA-ACTININ

ALPHA-ACTININ Suppliers list
Company Name: Sigma-Aldrich  
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ALPHA-ACTININ Basic information
Product Name:ALPHA-ACTININ
Synonyms:ALPHA-ACTININ;A-actinin from chicken gizzard;α-actinin from chicken gizzard;α-Actinin
CAS:11003-00-2
MF:
MW:0
EINECS:
Product Categories:Actin/Actin-binding ProteinsProteins and Derivatives;Actinin;Cell Signaling and Neuroscience;Cytoskeleton and Extracellular Matrix;Structural Proteins;proteins
Mol File:Mol File
ALPHA-ACTININ Structure
ALPHA-ACTININ Chemical Properties
storage temp. 2-8°C
form ammonium sulfate suspension
biological sourcechicken gizzard
Safety Information
WGK Germany 3
HS Code 3504009000
Storage Class10 - Combustible liquids
MSDS Information
ProviderLanguage
SigmaAldrich English
ALPHA-ACTININ Usage And Synthesis
Usesα-Actinin from chicken gizzard has been used:
  • as an antigen to coat plates for the capture of anti-actinin antibody using enzyme-linked immunosorbent assay (ELISA) from tumor cell line clones
  • in in vitro motility experiments to test its effect on actin filament movement
  • to coat cantilevers for strengthening fluorescently labeled actin filaments in force measurement studies

General Descriptionα-Actinin exists as a rod-shaped antiparallel dimer with two elongated subunits. The domain region contains an N-terminal actin-binding domain with tandem calponin homology domains, a central tandem 3-helix motifs, and EF-hand motifs at C-terminus. It belongs to the spectrin superfamily and is localized in actin structures.
Biochem/physiol Actionsα-Actinin binds actin and has the ability to crosslink actin cytoskeleton. It also plays a key role in the structural maintenance of the Z-disk of striated muscle.
ALPHA-ACTININ Preparation Products And Raw materials
Tag:ALPHA-ACTININ(11003-00-2) Related Product Information
Aluminum acetylacetonate SALCOMINE Ethyl isocyanoacetate COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) Cupric acetylacetonate Tosylmethyl isocyanide Benzyl isocyanide ANTI-ALPHA-ACTININ Antibody Ferric acetylacetonate tert-Butyl isocyanide 1,1,3,3-Tetramethylbutyl isocyanide Methyl isocyanoacetate N-Butylisocyanide 2,4-Pentanedione, silver derivative Dichloro(ethylenediamine)platinum(II) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)dysprosium(III) Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)europium(III)