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| | ANTI-ALPHA-ACTININ Antibody Basic information |
| | ANTI-ALPHA-ACTININ Antibody Chemical Properties |
| storage temp. | −20°C | | biological source | rabbit |
| Hazard Codes | Xn | | Risk Statements | 21/22 | | Safety Statements | 36/37 | | WGK Germany | 3 |
| | ANTI-ALPHA-ACTININ Antibody Usage And Synthesis |
| Uses | May be used in the study of skeletal muscle organization and in studies of the membrane anchorage sites of actin. | | General Description | α-actinin is a 100kD actin binding protein found in muscle as well as non-muscle cells. In smooth muscle, α-actinin is identified in dense bodies and plaques characteristic of tissues whereas it is associated with z-discs that define muscle sarcomas in normal skeletal muscle. Monoclonal anti-α-actinin antibody can be used in immunoblotting to study the membrane anchorage sites and immunochemical identification of α-actinin. It can also be used in immunofluorescence to study the localization of α-actinin in cultured cells and tissues. Mouse anti-α-actinin antibody reacts specifically with chicken fibroblasts. The product has also shown reactivity for mouse and human cells. | | Biochem/physiol Actions | αactinin regulates muscle contraction and cytoskeletal organization. It promotes cell migration and acts as an actin crosslinker. Mutations in the α-actinin gene is observed in heterogeneous hypertrophic cardiomyopathy and in juvenile onset atrial fibrillation. |
| | ANTI-ALPHA-ACTININ Antibody Preparation Products And Raw materials |
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