| Company Name: |
LGM Pharma |
| Tel: |
1-(800)-881-8210 |
| Email: |
inquiries@lgmpharma.com |
Piroheptine manufacturers
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| | Piroheptine Basic information |
| Product Name: | Piroheptine | | Synonyms: | piroheptine hydrochloride;Pyrrolidine, 3-(10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-ethyl-2-methyl-, hydrochloride (8CI, 9CI);Piroheptine HCl;Trimol | | CAS: | 16378-22-6 | | MF: | C22H25N.ClH | | MW: | 339.907 | | EINECS: | | | Product Categories: | | | Mol File: | 16378-22-6.mol |  |
| | Piroheptine Chemical Properties |
| Toxicity | LD50 in male mice, rats (mg/kg): 153, 600 orally; 19, 17 i.v.; 95, 110 i.p.; 109, 330 s.c. (Hitomi) |
| | Piroheptine Usage And Synthesis |
| Uses | Piroheptine hydrochloride is an anticholinergic agent to inhibit dopamine uptake. Piroheptine hydrochloride prevents loss of striatal dopamine induced by MPTP (HY-15608). Piroheptine hydrochloride can be used for research in Parkinson[1]. | | Definition | ChEBI: Piroheptine hydrochloride is the hydrochloride salt of piroheptine. It has a role as an antiparkinson drug and a muscarinic antagonist. It contains a piroheptine(1+). | | in vivo | Piroheptine hydrochloride (20 mg/kg; ip; singel dose, 30 min before MPTP injection) suppresses neurotoxicity of MPTP in mice model[1]. | Animal Model: | Male 8-week-old C57BL/6J mice (20-30 g)[1] | | Dosage: | 20 mg/kg | | Administration: | IP; 30 min before MPTP injection (10 mg/kg; 4 times with 1 h interval) | | Result: | Prevented loss of striatal dopamine. |
| | References | [1] Saitoh T. Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl. J Neurol Sci. 1988 Feb;83(2-3):161-6. DOI:10.1016/0022-510x(88)90065-2 |
| | Piroheptine Preparation Products And Raw materials |
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