2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)-

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2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- manufacturers
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- Basic information
Product Name:2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)-
Synonyms:2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)-;EP3 antagonist 3
CAS:1227827-88-4
MF:C21H18N2O4
MW:362.38
EINECS:
Product Categories:
Mol File:1227827-88-4.mol
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- Structure
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- Chemical Properties
density 1.328±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMSO : 250 mg/mL (689.88 mM; Need ultrasonic)
form Solid
pka5.09±0.70(Predicted)
color Off-white to light yellow
Safety Information
MSDS Information
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- Usage And Synthesis
UsesEP3 antagonist 3 (compound 2) is an orally active, potent and selective EP3 antagonist, with a pKi of 8.3. EP3 antagonist 3 shows excellent pharmacokinetic properties. EP3 antagonist 3 can be used for overactive bladder (OAB) research[1].
IC 50EP3: 8.3 (pKi)
References[1] Jin J, et al. Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett. 2010 May 14;1(7):316-20. DOI:10.1021/ml100077x
2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)- Preparation Products And Raw materials
Tag:2,4-Oxazolidinedione, 5-[1,2-dihydro-6-(2-naphthalenyl)-2-oxo-3-pyridinyl]-5-(1-methylethyl)-(1227827-88-4) Related Product Information
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