2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1)

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2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) Basic information
Product Name:2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1)
Synonyms:Inflammasome Inhibitor 4b
CAS:2768759-64-2
MF:C16H19N2O5S.Na
MW:374.39
EINECS:
Product Categories:
Mol File:2768759-64-2.mol
2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) Structure
2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) Chemical Properties
storage temp. Store at -20°C
solubility DMSO: soluble
form A crystalline solid
Safety Information
MSDS Information
2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) Usage And Synthesis
UsesNLRP3-IN-9 is a potent NLRP3 inhibitor. NLRP3-IN-9 inhibits IL-1β release. NLRP3-IN-9 reduces inflammation and mechanical hyperalgesia. NLRP3-IN-9 has the potential for the research of gout[1].
in vivo

NLRP3-IN-9 (3, 10 mg/kg; i.p.) reduces inflammation and mechanical hyperalgesia in a mouse model of acute gout[1].

Animal Model:3-4 month old male and female C57BL/6J WT and NLRP3-KO mice[1]
Dosage:3, 10 mg/kg
Administration:I.p.
Result:Reduced paw swelling by 40% in males and 33% in females at 3 mg/kg, and 66% in males and 52% in females at 10 mg/kg in WT mouse.
IC 50NLRP3
References[1] Narros-Fernández P, et al. Synthesis and Pharmacological Evaluation of New N-Sulfonylureas as NLRP3 Inflammasome Inhibitors: Identification of a Hit Compound to Treat Gout. J Med Chem. 2022 Apr 28;65(8):6250-6260. DOI:10.1021/acs.jmedchem.2c00149
2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) Preparation Products And Raw materials
Tag:2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1)(2768759-64-2) Related Product Information
NP3-146 sodium 2-Furansulfonamide, N-[[[4-chloro-2,6-bis(1-methylethyl)phenyl]amino]carbonyl]-4-(1-hydroxy-1-methylethyl)- MCC950 CP-456773 sodium 2-Furansulfonamide, N-[[(3,5-dimethylphenyl)amino]carbonyl]-4-(1-hydroxy-1-methylethyl)-, sodium salt, ion(1-) (1:1) NA