M-2912 manufacturers
- Tankyrase-IN-5
-
-
2026-07-27
- CAS:1460285-69-1
- Purity:
- Supply Ability: 10g
|
| Product Name: | M-2912 | | Synonyms: | M-2912;Pyrrolo[1,2-a]pyrazin-1(2H)-one, 3-[4-(1-hydroxy-1-methylethyl)phenyl]-7-methyl-;Tankyrase-IN-5 | | CAS: | 1460285-69-1 | | MF: | C17H18N2O2 | | MW: | 282.34 | | EINECS: | | | Product Categories: | | | Mol File: | 1460285-69-1.mol |  |
| | M-2912 Chemical Properties |
| Boiling point | 442.6±45.0 °C(Predicted) | | density | 1.20±0.1 g/cm3(Predicted) | | pka | 11.17±0.40(Predicted) |
| | M-2912 Usage And Synthesis |
| Uses | Tankyrase-IN-5 (Compound 30f), an analogue of MSC2504877 (HY-123851), is a tankyrase TNKS1 and TNKS2 inhibitor with IC50s of 2.3 nM and 7.9 nM, respectively[1]. | | References | [1] Buchstaller HP, et al. Optimization of a Screening Hit toward M2912, an Oral Tankyrase Inhibitor with Antitumor Activity in Colorectal Cancer Models. J Med Chem. 2021 Jul 22;64(14):10371-10392. DOI:10.1021/acs.jmedchem.1c00800 |
| | M-2912 Preparation Products And Raw materials |
|