Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)-

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Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- Basic information
Product Name:Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)-
Synonyms:Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)-;2-[(2-Amino-3-hydroxy-1-oxopropyl)amino]-2-[2-[5-(aminomethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl]-2-oxoethyl]propanedioic acid;Antibiotic K-16;Malonomicin;Propanedioic acid, 2-[(2-amino-3-hydroxy-1-oxopropyl)amino]-2-[2-[5-(aminomethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl]-2-oxoethyl]-
CAS:38249-71-7
MF:C13H18N4O9
MW:374.3
EINECS:
Product Categories:
Mol File:38249-71-7.mol
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- Structure
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- Chemical Properties
Boiling point 934.544±65.00 °C(Press: 760.00 Torr)(predicted)
density 1.706±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
pka1.525±0.10(predicted)
Safety Information
ToxicityLD50 intraperitoneal in mouse: 1gm/kg
MSDS Information
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- Usage And Synthesis
UsesMalonomicin (Antibiotic K16) is an antibiotic with anti-protozoa and anti-trypanosome activities. Malonomicin also shows anti-trypanosome activity in vivo[1][2].
in vivo

Malonomicin (30 mg/kg; i.p., once) eliminates the infection status of trypanosoma infected-mice and shows no harmful effects with daily dose of 50 mg/kg[2].

Animal Model:Mice with Trypanosoma congolense infection[2]
Dosage:30 mg/kg
Administration:Intraperitoneal injection; 30 mg/kg, once
Result:Eliminated all trypanosomes from in the blood of infected mice.
IC 50Trypanosoma
References[1] Emilio L. Ghisalberti. Bioactive Tetramic Acid Metabolites. Studies in Natural Products Chemistry. Volume 28, Part I, 2003, Pages 109-163.
[2] Ottens Hendrik and Vos Cornelis. Preparation of an antibiotic for the treatment of trypanosomiasis. NL6701356. 1967.
Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)- Preparation Products And Raw materials
Tag:Propanedioic acid, ((2-amino-3-hydroxy-1-oxopropyl)amino)(2-(5-(aminom ethyl)-2,5-dihydro-4-hydroxy-2-oxo-1H-pyrrol-3-yl)-2-oxoethyl)-(38249-71-7) Related Product Information
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