5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl-

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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- manufacturers
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- Basic information
Product Name:5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl-
Synonyms:5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl-;A1AR antagonist 2
CAS:1441961-74-5
MF:C17H12N4O
MW:288.3
EINECS:
Product Categories:
Mol File:1441961-74-5.mol
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- Structure
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- Chemical Properties
Boiling point 657.7±65.0 °C(Predicted)
density 1.40±0.1 g/cm3(Predicted)
pka8.71±0.10(Predicted)
Safety Information
MSDS Information
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- Usage And Synthesis
UsesA1AR antagonist 2 (compound 18h) is a potent A1 adenosine receptor (AR) antagonist with Kis of 1.49, 10.2, and 50.1 nM for hA1, hA2A and hA2B, respectively[1].
References[1] Val C, et al. Optimization of 2-Amino-4,6-diarylpyrimidine-5-carbonitriles as Potent and Selective A1 Antagonists. J Med Chem. 2022;65(3):2091-2106. DOI:10.1021/acs.jmedchem.1c01636
5-Pyrimidinecarbonitrile, 2-amino-4-(3-hydroxyphenyl)-6-phenyl- Preparation Products And Raw materials
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