L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester

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L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester manufacturers

  • COX-2-IN-17
  • COX-2-IN-17 pictures
  • $1980.00
  • 2026-04-20
  • CAS:2411390-10-6
  • Purity:
  • Supply Ability: 10g
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Basic information
Product Name:L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester
Synonyms:L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester;COX-2-IN-17
CAS:2411390-10-6
MF:C20H23ClN6O2
MW:414.89
EINECS:
Product Categories:
Mol File:2411390-10-6.mol
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Structure
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Chemical Properties
Boiling point 641.7±63.0 °C(Predicted)
density 1.45±0.1 g/cm3(Predicted)
pka6.82±0.10(Predicted)
Safety Information
MSDS Information
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Usage And Synthesis
UsesCOX-2-IN-17 (compound 10) is a potent and BBB-penetrated COX-2 (cyclooxygenase-2) inhibitor, with an IC50 of 0.02 μM. COX-2-IN-17 shows anti-inflammatory and analgesic activities. COX-2-IN-17 attenuates hyperalgesia in the neurogenic phase as well as the inflammatory phase[1].
IC 50COX-2: 0.02 μM (IC50); COX-1: >10 μM (IC50)
References[1] Kumari P, et al. Modification of the lead molecule: Tryptophan and piperidine appended triazines reversing inflammation and hyeperalgesia in rats. Bioorg Med Chem. 2020 Jan 15;28(2):115246. DOI:10.1016/j.bmc.2019.115246
L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester Preparation Products And Raw materials
Tag:L-Tryptophan, 1-[4-chloro-6-(1-piperidinyl)-1,3,5-triazin-2-yl]-, methyl ester(2411390-10-6) Related Product Information
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