|
|
| | 4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE Basic information |
| Product Name: | 4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE | | Synonyms: | AKOS B016097;4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE;4-(2-FURYL)-2-PYRIMIDINAMINE;4-(2-FURYL)-2-PYRIMIDINYLAMINE;4-(2-FURYL)PYRIMIDIN-2-AMINE;2-AMino-4-(2-furyl)pyriMidine;4-(furan-2-yl)pyrimidin-2-amine;[4-(2-furyl)pyrimidin-2-yl]amine | | CAS: | 206564-00-3 | | MF: | C8H7N3O | | MW: | 161.16 | | EINECS: | | | Product Categories: | | | Mol File: | 206564-00-3.mol |  |
| | 4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE Chemical Properties |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| HazardClass | IRRITANT | | HS Code | 2933599590 |
| | 4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE Usage And Synthesis |
| Synthesis | A suspension was formed with 3-(dimethylamino)-1-(furan-2-yl)prop-2-en-1-one (5.0 g, 30.3 mmol), guanidine hydrochloride (5.8 g, 60.7 mmol) and potassium carbonate (8.4 g, 60.9 mmol) in N,N-dimethylformamide (50 mL). The reaction mixture was stirred at 100 °C for 21 hours. After completion of the reaction, it was cooled to room temperature and diluted with ice water (250 mL). The resulting light brown solid 4-(2-furyl)pyrimidin-2-amine (4.19 g, 86% yield) was collected by filtration and washed with deionized water. The product was characterized by 1H NMR (400 MHz, DMSO-d6) and mass spectrometry (ESI): 1H NMR δ 6.66 (2H, br s), 6.68 (1H, dd, J = 2.0, 3.2 Hz), 6.88 (1H, d, J = 5.2 Hz), 7.17 (1H, dd, J = 0.8, 3.2 Hz), 7.88 (1H, dd, J = 0.8, 2.0 Hz), 8.28 (1H, d, J = 5.2 Hz); MS m/e (ESI) 162 (MH+). | | References | [1] Patent: EP1439175, 2004, A1. Location in patent: Page 46 |
| | 4-FURAN-2-YL-PYRIMIDIN-2-YLAMINE Preparation Products And Raw materials |
|