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| | sigmoidin B Basic information |
| Product Name: | sigmoidin B | | Synonyms: | sigmoidin B;(S)-2-[3,4-Dihydroxy-5-(3-methyl-2-butenyl)phenyl]-2,3-dihydro-5,7-dihydroxy-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one, 2-[3,4-dihydroxy-5-(3-methyl-2-buten-1-yl)phenyl]-2,3-dihydro-5,7-dihydroxy-, (2S)- | | CAS: | 87746-47-2 | | MF: | C20H20O6 | | MW: | 356.37 | | EINECS: | | | Product Categories: | | | Mol File: | 87746-47-2.mol |  |
| | sigmoidin B Chemical Properties |
| | sigmoidin B Usage And Synthesis |
| Uses | Sigmoidin B, a prenylated flavanone, is a selective 5-lipoxygenase inhibitor. Sigmoidin B is a potent scavenger of the DPPH radical. Sigmoidin B has antigenotoxic activity that inhibits genotoxicity induced by Aflatoxin B1 (HY-N6615), with an IC50 of 18.7 μg/mL. Sigmoidin B has anti-inflammatory activity and antioxidant properties[1][2]. | | Definition | ChEBI: A tetrahydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 5, 7, 3' and 4' and a prenyl group at position 5'. Isolated from Erythrina sigmoidea, it exhibits anti-inflammatory and antioxidant acti
ities. | | in vivo | In the assay of phospholipase A2-induced mouse paw oedema, Sigmoidin B (5 mg/kg, ip) inhibits oedema formation at 60 min. In the Phorbol 12-myristate 13-acetate (PMA) (HY-18739) test, Sigmoidin B decreases the induced oedema by 83%[1]. | | IC 50 | 5-Lipoxygenase | | References | [1] Njamen D, et al. Anti-inflammatory activities of two flavanones, sigmoidin A and sigmoidin B, from Erythrina sigmoidea. Planta Med. 2004 Feb;70(2):104-7. DOI:10.1055/s-2004-815484
[2] Zarev Y, et al. Antigenotoxic prenylated flavonoids from stem bark of Erythrina latissima. Phytochemistry. 2017 Sep;141:140-146. DOI:10.1016/j.phytochem.2017.06.003 |
| | sigmoidin B Preparation Products And Raw materials |
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