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Product Name:5-O-Methylembelin
CAS:56005-10-8
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| | 5-O-methylembelin Basic information |
| Product Name: | 5-O-methylembelin | | Synonyms: | 5-O-methylembelin;2-hydroxy-5-methoxy-3-undecylcyclohexa-2,5-diene-1,4-dione;2,5-Cyclohexadiene-1,4-dione, 2-hydroxy-5-methoxy-3-undecyl- | | CAS: | 56005-10-8 | | MF: | C18H28O4 | | MW: | 308.41 | | EINECS: | | | Product Categories: | | | Mol File: | 56005-10-8.mol |  |
| | 5-O-methylembelin Chemical Properties |
| Melting point | 88-90 °C(Solv: ethanol (64-17-5)) | | Boiling point | 439.5±45.0 °C(Predicted) | | density | 1.06±0.1 g/cm3(Predicted) | | pka | 2.95±0.50(Predicted) | | form | Solid | | color | Light yellow to yellow | | LogP | 5.940 (est) |
| | 5-O-methylembelin Usage And Synthesis |
| Uses | 5-O-Methylembelin is a natural isocoumarin that inhibits PCSK9, inducible degrader of the low-density lipoprotein receptor (IDLR), and sterol regulatory element binding protein 2 (SREBP2) mRNA expression[1]. | | Definition | ChEBI: A member of the class of monohydroxy-1,4-benzoquinones that is embelin in which the hydroxy group at position 5 is replaced by a methoxy group. Isolated from Lysimachia punctata and Embelia ribes, it exhibits antileishmanial activ
ty as well as inhibitory activity towards hepatitis C protease. | | References | [1] Pisey Pel, et al. Isocoumarins and Benzoquinones with Their Proprotein Convertase Subtilisin/Kexin Type 9 Expression Inhibitory Activities from Dried Roots of Lysimachia vulgaris. ACS Omega. 2022 Dec 8;7(50):47296-47305. DOI:10.1021/acsomega.2c06660 |
| | 5-O-methylembelin Preparation Products And Raw materials |
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