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BOC Sciences |
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16314854226; +8616314854226 |
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inquiry@bocsci.com |
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| | It 143-b Basic information |
| Product Name: | It 143-b | | Synonyms: | 4-Pyridinol, 2-[(2E,5E,7E,9R,10R,11E,13E)-10-hydroxy-3,7,9,11,13-pentamethyl-2,5,7,11,13-pentadecapentaen-1-yl]-5,6-dimethoxy-3-methyl-;2-[(2E,5E,7E,9R,10R,11E,13E)-10-hydroxy-3,7,9,11,13-pentamethyl-2,5,7,11,13-pentadecapentaen-1-yl]-5,6-dimethoxy-3-methyl-4-pyridinol;It 143-b | | CAS: | 183485-34-9 | | MF: | C28H41NO4 | | MW: | 455.63 | | EINECS: | | | Product Categories: | | | Mol File: | 183485-34-9.mol |  |
| | It 143-b Chemical Properties |
| Boiling point | 650.7±55.0 °C(Predicted) | | density | 1.033±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | form | An oil | | pka | 5.21±0.33(Predicted) |
| | It 143-b Usage And Synthesis |
| Description | IT-143B is a bacterial metabolite that has been found in S. iakyrus.1 It inhibits the proliferation of OS-RC-2 and ACHN cancer cells (IC50s = 22 and 98 μM, respectively). | | Uses | IT-143B is an antibiotic, that exhibits antibacterial activity against Micrococcus luteus with MIC of 6.25μg/mL. IT-143B inhibits growth of cancer cell KB with an IC50 of 1.1 ng/mL[1]. | | References | 1. Li, K., Liang, Z., Chen, W., et al. Iakyricidins A-D, antiproliferative piericidin analogues bearing a carbonyl group or cyclic skeleton from Streptomyces iakyrus SCSIO NS104 J. Org. Chem. 84(19),12626-12631(2019). |
| | It 143-b Preparation Products And Raw materials |
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